Concomitant Drug Treatment and Elimination in the RCC-affected Kidneys: Can We Kill Two Birds with One Stone?

Title:Concomitant Drug Treatment and Elimination in the RCC-affected Kidneys: Can We Kill Two Birds with One Stone?

Volume: 21 Issue: 13

Author(s): Muhammad Bilal Ahmed, Salman Ul Islam and Young Sup Lee*

Affiliation:

• School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu, 41566,Korea

Keywords: Renal cell carcinoma (RCC), drug eliminations, glomerular filtration rate (GFR), pharmacokinetic variability, surgery, dosage adjustments, and therapeutic interventions.

Abstract: Background: The kidneys are vital organs acting as the body’s filters that eliminate drugs and other waste products from the body. For effective cancer therapy, a delicate balance is required in the drug treatment and its elimination, which is critical for drug accumulation, toxicity, and kidney malfunction. However, how renal cell carcinoma (RCC) affects the kidneys in safely eliminating the byproducts of drug treatments in patients with severely dysregulated kidney functions had remained elusive. Recent advancements in dose adjustment have added to our understanding regarding how drug treatments could be effectively regulated in aberrant kidney cells, driving safe elimination and reducing drug accumulation and toxicity at the right time and space. Dose adjustment is the only standard systemic way applicable; however, it presents certain limitations. There is significant room for developing new strategies and alternatives to improve it.

Objectives: Our analysis of the available treatments in literature discusses the treatment and their safe eliminations. In this study, we give an overview of the measures that could be taken to maintain the elimination gradient of anti-cancer drugs and restore normal kidney function in RCC. Differential therapeutics of RCC/mRCC in various clinical phase trials and the interaction of targeted therapeutics in response to vascular endothelial growth factor (VEGF) were also discussed.

Conclusion: Such information might suggest a new direction in controlling treatment with safe elimination through dose adjustment and its associated alternatives in a judicious manner. A strategy to systematically focus on the safe elimination of anti-cancer drugs in RCC strongly needs advocating.

Cite this article as:

Ahmed Bilal Muhammad , Salman Ul Islam and Lee Sup Young *, Concomitant Drug Treatment and Elimination in the RCC-affected Kidneys: Can We Kill Two Birds with One Stone?, Current Drug Metabolism 2020; 21 (13) . https://dx.doi.org/10.2174/1389200221666201112112707

DOI https://dx.doi.org/10.2174/1389200221666201112112707	Print ISSN 1389-2002
Publisher Name Bentham Science Publisher	Online ISSN 1875-5453