Abstract
Diagnosis of cancer in the early stages can help treat efficiently and reduce cancerrelated death. Cancer biomarkers can respond to the presence of cancer in body fluids before the appearance of any other symptoms of cancer. The integration of nanomaterials into biosensors as electrochemical platforms offer rapid, sensitive detection for cancer biomarkers. The use of surface- modified electrodes by carbon nanomaterials and metal nanoparticles enhances the performance of electrochemical analysis in biosensing systems through the increase of bioreceptors loading capacity on the surface. In this review, novel approaches based on nanomaterial-modified systems in the point of care diagnostics are highlighted.
Keywords: Cancer biomarkers, electrochemical-based biosensor, surface modified electrode, carbon nanomaterial, metal nanoparticles, bioreceptors
Graphical Abstract
[http://dx.doi.org/10.1016/j.jpba.2018.10.017] [PMID: 30366148]
[http://dx.doi.org/10.1016/j.trac.2019.07.020]
[http://dx.doi.org/10.1016/j.molonc.2012.01.010] [PMID: 22356776]
[http://dx.doi.org/10.1016/j.talanta.2019.120251] [PMID: 31514848]
[http://dx.doi.org/10.1039/C4CS00370E] [PMID: 25739971]
[http://dx.doi.org/10.1039/C9TB02579K] [PMID: 31999289]
[http://dx.doi.org/10.1016/j.bios.2019.111416] [PMID: 31279179]
[http://dx.doi.org/10.1016/j.bios.2013.12.025] [PMID: 24462797]
[http://dx.doi.org/10.1002/elan.201501174]
[http://dx.doi.org/10.1021/cr100420s] [PMID: 21774490]
[http://dx.doi.org/10.1016/j.bios.2019.01.008] [PMID: 30708263]
[http://dx.doi.org/10.1016/j.bios.2018.07.019] [PMID: 30056302]
[http://dx.doi.org/10.1016/j.jobcr.2015.12.002] [PMID: 27195214]
[http://dx.doi.org/10.1021/acssensors.7b00868] [PMID: 29308651]
[http://dx.doi.org/10.1016/j.sna.2018.06.038]
[http://dx.doi.org/10.1016/j.sna.2019.06.020]
[http://dx.doi.org/10.1109/JSEN.2019.2935480]
[http://dx.doi.org/10.1021/acsami.8b16837] [PMID: 30525376]
[http://dx.doi.org/10.1016/j.bios.2019.01.059] [PMID: 30797108]
[http://dx.doi.org/10.1016/j.bios.2018.11.026] [PMID: 30554099]
[http://dx.doi.org/10.1016/j.watres.2019.05.018] [PMID: 31102860]
[http://dx.doi.org/10.1038/s41467-019-13648-7] [PMID: 31857585]
[http://dx.doi.org/10.1016/j.memsci.2006.05.021]
[http://dx.doi.org/10.1016/j.memsci.2006.10.020]
[http://dx.doi.org/10.1080/17458080.2016.1188223]
[http://dx.doi.org/10.1039/c3ta12433a]
[http://dx.doi.org/10.1007/s10311-010-0289-8]
[http://dx.doi.org/10.1016/j.molliq.2020.113185]
[http://dx.doi.org/10.1007/s12161-014-9926-3]
[http://dx.doi.org/10.1016/j.foodchem.2015.03.153] [PMID: 25952889]
[http://dx.doi.org/10.1002/elan.201100465]
[http://dx.doi.org/10.1016/j.jelechem.2018.01.034]
[http://dx.doi.org/10.1016/j.electacta.2018.02.033]
[http://dx.doi.org/10.3390/molecules22071048] [PMID: 28672780]
[http://dx.doi.org/10.1016/j.jcis.2019.10.007] [PMID: 31670018]
[http://dx.doi.org/10.1016/j.jcis.2019.07.047] [PMID: 31330427]
[http://dx.doi.org/10.1007/s11694-019-00096-6]
[http://dx.doi.org/10.1016/j.compositesb.2019.05.065]
[http://dx.doi.org/10.1016/j.molliq.2019.112040]
[http://dx.doi.org/10.1016/j.ceramint.2019.07.072]
[http://dx.doi.org/10.1016/j.ceramint.2019.05.113]
[http://dx.doi.org/10.1016/j.ceramint.2019.05.154]
[http://dx.doi.org/10.1039/C5AY03284A]
[http://dx.doi.org/10.1016/j.trac.2016.01.032]
[http://dx.doi.org/10.1016/j.trac.2015.12.017]
[http://dx.doi.org/10.1016/j.bios.2012.06.019] [PMID: 22770827]
[http://dx.doi.org/10.1016/j.jhazmat.2016.10.057] [PMID: 27810324]
[http://dx.doi.org/10.1149/2.0021812jes]
[http://dx.doi.org/10.1016/j.bios.2014.08.080] [PMID: 25223552]
[http://dx.doi.org/10.1016/j.molliq.2014.03.049]
[http://dx.doi.org/10.1088/1742-6596/704/1/012011]
[http://dx.doi.org/10.1149/2.0252003JES]
[http://dx.doi.org/10.1039/b714449k] [PMID: 20419217]
[http://dx.doi.org/10.1016/j.trac.2015.03.006]
[http://dx.doi.org/10.3390/s17081919] [PMID: 28825646]
[http://dx.doi.org/10.1016/j.jcis.2020.01.089] [PMID: 32032811]
[http://dx.doi.org/10.1016/j.bios.2018.02.013] [PMID: 29448224]
[http://dx.doi.org/10.1016/j.mtcomm.2016.03.008]
[http://dx.doi.org/10.1016/j.ceramint.2018.09.273]
[http://dx.doi.org/10.1016/j.molliq.2019.01.081]
[http://dx.doi.org/10.1039/C8NJ05581E]
[http://dx.doi.org/10.3390/membranes8020024] [PMID: 29757953]
[http://dx.doi.org/10.1016/j.snb.2019.04.075]
[http://dx.doi.org/10.1007/s00604-014-1308-4] [PMID: 25568497]
[http://dx.doi.org/10.1016/j.bios.2015.04.018] [PMID: 25884734]
[http://dx.doi.org/10.1016/j.snb.2015.06.066]
[http://dx.doi.org/10.1016/j.bios.2015.06.063] [PMID: 26176209]
[http://dx.doi.org/10.1016/j.bios.2016.07.114] [PMID: 27520500]
[http://dx.doi.org/10.1016/j.bios.2017.04.020] [PMID: 28433858]
[http://dx.doi.org/10.1038/s41565-018-0232-x] [PMID: 30150634]
[http://dx.doi.org/10.1016/j.trac.2017.12.019]
[http://dx.doi.org/10.1007/s00604-019-3410-0] [PMID: 31037494]
[http://dx.doi.org/10.1021/acs.chemrev.6b00220] [PMID: 27428515]
[http://dx.doi.org/10.1016/j.bios.2015.01.066] [PMID: 25660660]
[http://dx.doi.org/10.1016/j.bios.2016.12.014] [PMID: 27984706]
[http://dx.doi.org/10.1016/j.trac.2019.05.014]
[http://dx.doi.org/10.1016/j.bios.2019.01.047] [PMID: 30771717]
[http://dx.doi.org/10.1016/j.talanta.2019.120669] [PMID: 31987212]
[http://dx.doi.org/10.1016/j.bios.2020.112018] [PMID: 32056737]
[http://dx.doi.org/10.1080/10408347.2018.1561243] [PMID: 30648398]
[http://dx.doi.org/10.1149/2.1261906jes]
[http://dx.doi.org/10.3390/s19020392] [PMID: 30669367]
[http://dx.doi.org/10.1039/C8RA09577A]
[http://dx.doi.org/10.2147/IJN.S189730] [PMID: 30936693]
[http://dx.doi.org/10.1016/j.bios.2020.112212] [PMID: 32364933]
[http://dx.doi.org/10.2116/analsci.27.409] [PMID: 21478617]
[http://dx.doi.org/10.1016/j.colsurfb.2012.12.011] [PMID: 23314609]
[http://dx.doi.org/10.1016/j.bios.2016.07.086] [PMID: 27494812]
[http://dx.doi.org/10.1016/j.snb.2012.10.098]
[http://dx.doi.org/10.1016/j.bios.2014.03.055] [PMID: 24755294]
[http://dx.doi.org/10.1016/j.bios.2013.04.029] [PMID: 23707873]
[http://dx.doi.org/10.1007/s12161-013-9585-9]
[http://dx.doi.org/10.1016/j.lwt.2014.01.023]
[http://dx.doi.org/10.2147/IJN.S189728] [PMID: 30880972]
[http://dx.doi.org/10.1021/jp071604t]
[http://dx.doi.org/10.1039/C7NJ04430E]
[http://dx.doi.org/10.1021/acs.analchem.5b01761] [PMID: 26313137]
[http://dx.doi.org/10.1016/j.talanta.2017.08.027] [PMID: 28917742]
[http://dx.doi.org/10.1016/j.jfca.2017.06.006]
[http://dx.doi.org/10.1002/elan.201501014]
[http://dx.doi.org/10.1007/s00604-019-3619-y] [PMID: 31270702]
[http://dx.doi.org/10.1007/s00604-018-2918-z] [PMID: 30094655]
[http://dx.doi.org/10.1016/j.matchemphys.2020.123042]
[http://dx.doi.org/10.1016/j.nanoso.2017.09.013]
[http://dx.doi.org/10.1016/j.memsci.2019.117210]
[http://dx.doi.org/10.1016/j.memsci.2019.117687]
[http://dx.doi.org/10.1002/admi.201801427]
[http://dx.doi.org/10.1016/j.apsusc.2018.01.237]
[http://dx.doi.org/10.1021/acs.chemrev.5b00008] [PMID: 25997028]
[http://dx.doi.org/10.1016/j.snb.2017.08.009]
[http://dx.doi.org/10.1016/j.bios.2018.08.067] [PMID: 30196046]
[http://dx.doi.org/10.1007/s00604-019-3565-8] [PMID: 31256262]
[http://dx.doi.org/10.1002/adma.201500323] [PMID: 26045099]
[http://dx.doi.org/10.1016/j.foodchem.2020.126172] [PMID: 31951890]
[http://dx.doi.org/10.1038/srep20511] [PMID: 26842737]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.07.069] [PMID: 28711617]
[http://dx.doi.org/10.1002/smll.201402648] [PMID: 25521301]
[http://dx.doi.org/10.1007/s00604-018-2688-7] [PMID: 29594483]
[http://dx.doi.org/10.1016/j.snb.2017.10.105]
[http://dx.doi.org/10.1016/j.trac.2019.04.003]
[http://dx.doi.org/10.1016/j.bios.2013.09.003] [PMID: 24064477]
[http://dx.doi.org/10.1016/j.snb.2019.127281]
[http://dx.doi.org/10.1016/j.bios.2019.03.043] [PMID: 30952013]
[http://dx.doi.org/10.1007/s00604-016-1946-9]
[http://dx.doi.org/10.1016/j.foodchem.2014.02.082] [PMID: 24731323]
[http://dx.doi.org/10.1016/j.foodchem.2013.07.020] [PMID: 23993620]
[http://dx.doi.org/10.1007/s11664-016-5172-3]
[http://dx.doi.org/10.1166/jnn.2015.10038] [PMID: 26504948]
[http://dx.doi.org/10.1039/C6RA09050H]
[http://dx.doi.org/10.1016/j.molliq.2017.09.119]
[http://dx.doi.org/10.1007/s00604-017-2143-1]
[http://dx.doi.org/10.1016/j.bios.2015.08.044] [PMID: 26318579]
[http://dx.doi.org/10.1016/j.enzmictec.2017.10.009] [PMID: 29499779]
[http://dx.doi.org/10.1002/jbm.a.35425] [PMID: 25690431]
[http://dx.doi.org/10.1016/j.seppur.2018.05.006]
[http://dx.doi.org/10.1016/j.molliq.2016.08.064]
[http://dx.doi.org/10.1016/j.bios.2016.08.004] [PMID: 27591721]
[http://dx.doi.org/10.1016/j.snb.2017.09.111]
[http://dx.doi.org/10.1016/j.bios.2015.12.030] [PMID: 26718548]
[http://dx.doi.org/10.1016/j.fbp.2016.07.016]
[http://dx.doi.org/10.5004/dwt.2017.20127]
[http://dx.doi.org/10.1016/j.enmm.2017.09.001]
[http://dx.doi.org/10.1039/C7RA11866J]
[http://dx.doi.org/10.1002/macp.201700350]
[http://dx.doi.org/10.1016/j.msec.2016.05.056] [PMID: 27523989]
[http://dx.doi.org/10.1016/j.bios.2016.12.052] [PMID: 28056439]
[http://dx.doi.org/10.1016/j.jelechem.2017.12.076]
[http://dx.doi.org/10.1016/j.aca.2018.12.053] [PMID: 30797454]
[http://dx.doi.org/10.1021/acs.iecr.5b03147]
[http://dx.doi.org/10.1016/j.memsci.2016.07.003]
[http://dx.doi.org/10.1016/j.memsci.2014.08.016]
[http://dx.doi.org/10.3390/molecules24162924] [PMID: 31409035]
[http://dx.doi.org/10.1021/acs.langmuir.7b00537] [PMID: 28489410]
[http://dx.doi.org/10.1016/j.ultsonch.2019.104783] [PMID: 31937440]
[http://dx.doi.org/10.1016/j.msec.2017.03.260] [PMID: 28532103]
[http://dx.doi.org/10.29252/jcc.1.1.1]
[http://dx.doi.org/10.1016/j.bios.2017.07.068] [PMID: 28763783]
[http://dx.doi.org/10.1021/acs.analchem.6b00144] [PMID: 26910366]
[http://dx.doi.org/10.1016/j.bios.2016.12.043] [PMID: 28013019]