Login Register Cart 0
Generic placeholder image

Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Evaluation of Left Ventricular Volumes and Ejection Fraction from Gated Myocardial Perfusion SPECT Processed with “Myovation Evolution”: Comparison of Three Automated Software Packages using Cardiac Magnetic Resonance as Reference

Author(s): Enrico Calandri*, Francesca Guana, Mirco Pultrone, Stefano Leuzzi, Giovanna Chiorino, Eleonora Soligo, Viviana Frantellizzi, Sonya Gallina, Mauro Liberatore and Giuseppe De Vincentis

Volume 14, Issue 2, 2021

Published on: 15 September, 2020

Page: [112 - 120] Pages: 9

DOI: 10.2174/1874471013666200915130100

Price: $65

Abstract

Background : The development of resolution recovery (RR) algorithms has made it possible to preserve the good quality of cardiac images despite a reduced number of counts during study acquisition.

Objective: Our purpose was to evaluate the performance of three different software packages in the quantification of left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) from gated perfusion SPECT, applying a resolution recovery (RR) algorithm (GE Myovation Evolution), with respect to cardiac MRI (cMRI) as a gold standard.

Methods: We retrospectively enrolled 21 patients, with suspected or known coronary heart disease. Images at rest were reconstructed by filtered back projection (FBP) and by an iterative protocol with the RR algorithm. EDV, ESV, and LVEF were automatically computed employing Quantitative Gated SPECT (QGS), Myometrix (MX), and Corridor 4DM (4DM). Any difference in EDV, ESV, and LVEF calculation between cMRI and the three packages (with FBP and iterative reconstruction with RR) was tested using Wilcoxon or paired t-test, with the assumption of normality assessed using the Shapiro-Wilk test. Agreement between imaging reconstruction algorithms and between gated-SPECT software packages and cMRI was studied with Pearson’s (r) or Spearman’s (R) correlation coefficients and Lin’s concordance correlation coefficient (LCC).

Results: Intra-software evaluation always revealed very strong correlation coefficients (R, r ≥ 0.8) and excellent LCC coefficients (LCC > 0.95), except for the LCC coefficient between MX-FBP and MX-RR in EDV evaluation, nevertheless considered very good (LCC = 0.94). EDV and ESV had significantly lower value when calculated with the RR algorithm with respect to FBP reconstruction in QGS and MX. LVEF estimation did not show significant differences for QGS-FBP, QGS-RR, MX, and 4DM-RR with respect to cMRI.

Conclusion: All reconstruction methods systematically underestimate EDV and ESV, with higher underestimation applying only the RR. No significant differences were observed between 4DM - RR and 4DM-FBP, for each parameter, when the 4DM package was used.

Keywords: Gated perfusion SPECT, resolution recovery, quantitative gated SPECT, myometrix, corridor 4DM, cardiac magnetic resonance imaging, left ventricular volumes, left ventricular ejection fraction.

« Previous Next »
Graphical Abstract

[1]
Faber, T.L.; Cooke, C.D.; Folks, R.D.; Vansant, J.P.; Nichols, K.J.; DePuey, E.G.; Pettigrew, R.I.; Garcia, E.V. Left ventricular function and perfusion from gated SPECT perfusion images: an integrated method. J. Nucl. Med., 1999, 40(4), 650-659.
[PMID: 10210225]
[2]
Einstein, A.J.; Moser, K.W.; Thompson, R.C.; Cerqueira, M.D.; Henzlova, M.J. Radiation dose to patients from cardiac diagnostic imaging. Circulation, 2007, 11 116(11), 1290-1305.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.107.688101]
[3]
Dulce, M.C.; Mostbeck, G.H.; Friese, K.K.; Caputo, G.R.; Higgins, C.B. Quantification of the left ventricular volumes and function with cine MR imaging: comparison of geometric models with three-dimensional data. Radiology, 1993, 188(2), 371-376.
[http://dx.doi.org/10.1148/radiology.188.2.8327680] [PMID: 8327680]
[4]
Pattynama, P.M.; De Roos, A.; Van der Wall, E.E.; Van Voorthuisen, A.E. Evaluation of cardiac function with magnetic resonance imaging. Am. Heart J., 1994, 128(3), 595-607.
[http://dx.doi.org/10.1016/0002-8703(94)90636-X] [PMID: 8074024]
[5]
Collins, J.D. Global and regional functional assessment of ischemic heart disease with cardiac MR imaging. Radiol. Clin. North Am., 2015, 53(2), 369-395.
[http://dx.doi.org/10.1016/j.rcl.2014.11.001] [PMID: 25727001]
[6]
Kinno, M.; Nagpal, P.; Horgan, S.; Waller, A.H. Comparison of Echocardiography, Cardiac Magnetic Resonance, and Computed Tomographic Imaging for the Evaluation of Left Ventricular Myocardial Function: Part 1 (Global Assessment). Curr. Cardiol. Rep., 2017, 19(1), 9.
[http://dx.doi.org/10.1007/s11886-017-0815-4] [PMID: 28176279]
[7]
Germano, G.; Kiat, H.; Kavanagh, P.B.; Moriel, M.; Mazzanti, M.; Su, H.T.; Van Train, K.F.; Berman, D.S. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J. Nucl. Med., 1995, 36(11), 2138-2147.
[PMID: 7472611]
[8]
Farkash, G.; Kenig, T.; Grabnic, M.; Yuzefovich, B.; Sachs, J.; Bocher, M. Volumetric Quantitation of Left Ventricular Perfusion and Function from Myocardial Perfusion SPECT: Validation of a New Algorithm. J. Nucl. Cardiol., 2006, 13(4), S5-S6.
[http://dx.doi.org/10.1016/j.nuclcard.2006.06.016]
[9]
Ficaro, E.P.; Lee, B.C.; Kritzman, J.N.; Corbett, J.R. Corridor4DM: the Michigan method for quantitative nuclear cardiology. J. Nucl. Cardiol., 2007, 14(4), 455-465.
[http://dx.doi.org/10.1016/j.nuclcard.2007.06.006] [PMID: 17679053]
[10]
Bavelaar-Croon, C.D.; Kayser, H.W.; van der Wall, E.E.; de Roos, A.; Dibbets-Schneider, P.; Pauwels, E.K.; Germano, G.; Atsma, D.E. Left ventricular function: correlation of quantitative gated SPECT and MR imaging over a wide range of values. Radiology, 2000, 217(2), 572-575.
[http://dx.doi.org/10.1148/radiology.217.2.r00nv15572] [PMID: 11058662]
[11]
Bax, J.J.; Lamb, H.; Dibbets, P.; Pelikan, H.; Boersma, E.; Viergever, E.P.; Germano, G.; Vliegen, H.W.; de Roos, A.; Pauwels, E.K.; Van der Wall, E.E. Comparison of gated single-photon emission computed tomography with magnetic resonance imaging for evaluation of left ventricular function in ischemic cardiomyopathy. Am. J. Cardiol., 2000, 86(12), 1299-1305.
[http://dx.doi.org/10.1016/S0002-9149(00)01231-5] [PMID: 11113402]
[12]
Faber, T.L.; Vansant, J.P.; Pettigrew, R.I.; Galt, J.R.; Blais, M.; Chatzimavroudis, G.; Cooke, C.D.; Folks, R.D.; Waldrop, S.M.; Gurtler-Krawczynska, E.; Wittry, M.D.; Garcia, E.V. Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: comparison of two methods. J. Nucl. Cardiol., 2001, 8(6), 645-651.
[http://dx.doi.org/10.1067/mnc.2001.117173] [PMID: 11725260]
[13]
Lipke, C.S.; Kühl, H.P.; Nowak, B.; Kaiser, H.J.; Reinartz, P.; Koch, K.C.; Buell, U.; Schaefer, W.M. Validation of 4D-MSPECT and QGS for quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPET: comparison with cardiac magnetic resonance imaging. Eur. J. Nucl. Med. Mol. Imaging, 2004, 31(4), 482-490.
[http://dx.doi.org/10.1007/s00259-003-1411-y] [PMID: 14722679]
[14]
Persson, E.; Carlsson, M.; Palmer, J.; Pahlm, O.; Arheden, H. Evaluation of left ventricular volumes and ejection fraction by automated gated myocardial SPECT versus cardiovascular magnetic resonance. Clin. Physiol. Funct. Imaging, 2005, 25(3), 135-141.
[http://dx.doi.org/10.1111/j.1475-097X.2005.00599.x] [PMID: 15888092]
[15]
Schaefer, W.M.; Lipke, C.S.; Standke, D.; Kühl, H.P.; Nowak, B.; Kaiser, H.J.; Koch, K.C.; Buell, U. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation and comparison of the Emory Cardiac Tool Box with QGS and 4D-MSPECT. J. Nucl. Med., 2005, 46(8), 1256-1263.
[PMID: 16085580]
[16]
Stegger, L.; Lipke, C.S.; Kies, P.; Nowak, B.; Schober, O.; Buell, U.; Schäfers, M.; Schaefer, W.M. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: validation of an elastic surface model approach in comparison to cardiac magnetic resonance imaging, 4D-MSPECT and QGS. Eur. J. Nucl. Med. Mol. Imaging, 2007, 34(6), 900-909.
[http://dx.doi.org/10.1007/s00259-006-0322-0] [PMID: 17216166]
[17]
Winz, O.H.; Meyer, P.T.; Knollmann, D.; Lipke, C.S.; Kühl, H.P.; Oelve, C.; Schaefer, W.M. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation of the EXINI heart software package. Clin. Physiol. Funct. Imaging, 2009, 29(2), 89-94.
[http://dx.doi.org/10.1111/j.1475-097X.2008.00840.x] [PMID: 19076730]
[18]
Hedeer, F.; Palmer, J.; Arheden, H.; Ugander, M. Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages. BMC Med. Imaging, 2010, 10, 10.
[http://dx.doi.org/10.1186/1471-2342-10-10] [PMID: 20500866]
[19]
Mistry, N.; Halvorsen, S.; Hoffmann, P.; Müller, C.; Bøhmer, E.; Kjeldsen, S.E.; Bjørnerheim, R. Assessment of left ventricular function with magnetic resonance imaging vs. echocardiography, contrast echocardiography, and single-photon emission computed tomography in patients with recent ST-elevation myocardial infarction. Eur. J. Echocardiogr., 2010, 11(9), 793-800.
[PMID: 20525984]
[20]
Soneson, H.; Hedeer, F.; Arévalo, C.; Carlsson, M.; Engblom, H.; Ubachs, J.F.; Arheden, H.; Heiberg, E. Development and validation of a new automatic algorithm for quantification of left ventricular volumes and function in gated myocardial perfusion SPECT using cardiac magnetic resonance as reference standard. J. Nucl. Cardiol., 2011, 18(5), 874-885.
[http://dx.doi.org/10.1007/s12350-011-9427-3] [PMID: 21761374]
[21]
Ali, I.; Ruddy, T.D.; Almgrahi, A.; Anstett, F.G.; Wells, R.G. Half-time SPECT myocardial perfusion imaging with attenuation correction. J. Nucl. Med., 2009, 50(4), 554-562.
[http://dx.doi.org/10.2967/jnumed.108.058362] [PMID: 19289436]
[22]
Valenta, I.; Treyer, V.; Husmann, L.; Gaemperli, O.; Schindler, M.J.; Herzog, B.A.; Veit-Heibach, P.; Buechel, R.R.; Nkoulou, R.; Pazhenkottil, A.P.; Kaufmann, P.A. New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT. Eur. J. Nucl. Med. Mol. Imaging, 2010, 37(4), 750-757.
[http://dx.doi.org/10.1007/s00259-009-1300-0] [PMID: 19921186]
[23]
Filipczak, K.; Kuśmierek, J.; Drożdż, J.; Chiżyński, K.; Kasprzak, J.D.; Peruga, J.Z.; Płachcińska, A. Comparison of shortened gated myocardial perfusion imaging processed with “Myovation Evolution” with full time study. Nucl. Med. Rev. Cent. East. Eur., 2017, 20(1), 25-31.
[http://dx.doi.org/10.5603/NMR.a2016.0041] [PMID: 28198518]
[24]
Zafrir, N.; Solodky, A.; Ben-Shlomo, A.; Mats, I.; Nevzorov, R.; Battler, A.; Gutstein, A. Feasibility of myocardial perfusion imaging with half the radiation dose using ordered-subset expectation maximization with resolution recovery software. J. Nucl. Cardiol., 2012, 19(4), 704-712.
[http://dx.doi.org/10.1007/s12350-012-9552-7] [PMID: 22527795]
[25]
Armstrong, I.S.; Arumugam, P.; James, J.M.; Tonge, C.M.; Lawson, R.S. Reduced-count myocardial perfusion SPECT with resolution recovery. Nucl. Med. Commun., 2012, 33(2), 121-129.
[http://dx.doi.org/10.1097/MNM.0b013e32834e10d5] [PMID: 22107994]
[26]
Lawson, R.S.; White, D.; Nijran, K.; Cade, S.C.; Hall, D.O.; Kenny, B.; Knight, A.; Livieratos, L.; Murray, A.; Towey, D. Institute of Physics and Engineering in Medicine, Nuclear Medicine Software Quality Group. An audit of half-count myocardial perfusion imaging using resolution recovery software. Nucl. Med. Commun., 2014, 35(5), 511-521.
[http://dx.doi.org/10.1097/MNM.0000000000000078] [PMID: 24448215]
[27]
Enevoldsen, L.H.; Menashi, C.A.; Andersen, U.B.; Jensen, L.T.; Henriksen, O.M. Effects of acquisition time and reconstruction algorithm on image quality, quantitative parameters, and clinical interpretation of myocardial perfusion imaging. J. Nucl. Cardiol., 2013, 20(6), 1086-1092.
[http://dx.doi.org/10.1007/s12350-013-9775-2] [PMID: 23963600]
[28]
Plateau, A.; Bouvet, C.; Merlin, C.; Pereira, B.; Barres, B.; Clerfond, G.; Cachin, F.; Cassagnes, L. Assessment of four different cardiac softwares for evaluation of LVEF with CZT-SPECT vs CMR in 48 patients with recent STEMI. J. Nucl. Cardiol., 2018.
[http://dx.doi.org/10.1007/s12350-018-01493-y] [PMID: 30426398]
[29]
Benjamin, E.J.; Muntner, P.; Alonso, A.; Bittencourt, M.S.; Callaway, C.W.; Carson, A.P.; Chamberlain, A.M.; Chang, A.R.; Cheng, S.; Das, S.R.; Delling, F.N.; Djousse, L.; Elkind, M.S.V.; Ferguson, J.F.; Fornage, M.; Jordan, L.C.; Khan, S.S.; Kissela, B.M.; Knutson, K.L.; Kwan, T.W.; Lackland, D.T.; Lewis, T.T.; Lichtman, J.H.; Longenecker, C.T.; Loop, M.S.; Lutsey, P.L.; Martin, S.S.; Matsushita, K.; Moran, A.E.; Mussolino, M.E.; O’Flaherty, M.; Pandey, A.; Perak, A.M.; Rosamond, W.D.; Roth, G.A.; Sampson, U.K.A.; Satou, G.M.; Schroeder, E.B.; Shah, S.H.; Spartano, N.L.; Stokes, A.; Tirschwell, D.L.; Tsao, C.W.; Turakhia, M.P.; VanWagner, L.B.; Wilkins, J.T.; Wong, S.S.; Virani, S.S. American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation, 2019, 139(10), e56-e528.
[http://dx.doi.org/10.1161/CIR.0000000000000659] [PMID: 30700139]
[30]
Evolution for Cardiac. GE Healthcare, 2007. www3.gehealthcare.com.au/~/media/documents/us-global/products/nuclear-medicine/whitepaper/apps/gehealthcare-whitepaper_evolution-for-cardiac.pdf [accessed September 2, 2019].
[31]
Johnson, L.L.; Verdesca, S.A.; Aude, W.Y.; Xavier, R.C.; Nott, L.T.; Campanella, M.W.; Germano, G. Postischemic stunning can affect left ventricular ejection fraction and regional wall motion on post-stress gated sestamibi tomograms. J. Am. Coll. Cardiol., 1997, 30(7), 1641-1648.
[http://dx.doi.org/10.1016/S0735-1097(97)00388-4] [PMID: 9385888]
[32]
Hashimoto, J.; Kubo, A.; Iwasaki, R.; Iwanaga, S.; Mitamura, H.; Ogawa, S.; Kosuda, S. Gated single-photon emission tomography imaging protocol to evaluate myocardial stunning after exercise. Eur. J. Nucl. Med., 1999, 26(12), 1541-1546.
[http://dx.doi.org/10.1007/s002590050492] [PMID: 10638404]
[33]
Navare, S.M.; Wackers, F.J.; Liu, Y.H. Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction. Eur. J. Nucl. Med. Mol. Imaging, 2003, 30(10), 1330-1337.
[http://dx.doi.org/10.1007/s00259-003-1231-0] [PMID: 12838373]
[34]
Prewitt, R.M.; Oppenheimer, L.; Sutherland, J.B.; Wood, L.D. Effect of positive end-expiratory pressure on left ventricular mechanics in patients with hypoxemic respiratory failure. Anesthesiology, 1981, 55(4), 409-415.
[http://dx.doi.org/10.1097/00000542-198110000-00012] [PMID: 7027829]
[35]
Hesse, B.; Tägil, K.; Cuocolo, A.; Anagnostopoulos, C.; Bardiés, M.; Bax, J.; Bengel, F.; Busemann Sokole, E.; Davies, G.; Dondi, M.; Edenbrandt, L.; Franken, P.; Kjaer, A.; Knuuti, J.; Lassmann, M.; Ljungberg, M.; Marcassa, C.; Marie, P.Y.; McKiddie, F.; O’Connor, M.; Prvulovich, E.; Underwood, R.; van Eck-Smit, B. EANM/ESC Group. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur. J. Nucl. Med. Mol. Imaging, 2005, 32(7), 855-897.
[http://dx.doi.org/10.1007/s00259-005-1779-y] [PMID: 15909197]

Rights & Permissions Print Cite
Article Metrics
11
© 2024 Bentham Science Publishers | Privacy Policy