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Current Nanomedicine

Editor-in-Chief

ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

Review Article

A Critical Review on Potential Advancements of Nanostructured Lipid Carriers in Drug Delivery

Author(s): Pritam Kamble and Prabha Singh*

Volume 10, Issue 4, 2020

Page: [298 - 325] Pages: 28

DOI: 10.2174/2468187310999200818110030

Price: $65

Abstract

Nanostructured Lipid Carriers (NLCs) are second generation solid lipid nanoparticles (SLN) comprising of biocompatible solid-lipid and liquid-lipid along with an emulsifier. It exhibits superiority over conventional colloidal delivery systems in terms of enhanced drug loading, improved storage stability, increased biocompatibility and bioavailability, which allows researchers to explore their utility as delivery systems for proteins and small molecules. This review aims at discussing NLCs in-depth with regards to their application as drug delivery vehicles. A comprehensive discussion about the structural make-up, production techniques, and physico-chemical characterization have been elaborated along with an emphasis on various routes of administration for NLC delivery like ocular, pulmonary, oral, parenteral, and topical. This review also sheds light on the utility of NLCs in the field of cosmeceutical and herbal therapies. All summarized information in this extensive review exemplifies assurance for NLCs to be used as novel therapeutics for multiple disorders and highlights the versatility of the carrier system in pharmaceutical technology.

Keywords: High-pressure homogenization, lipid-particulate system, nanostructured lipid carriers, nanotechnology, solid lipid nanoparticles, physico-chemical characterization.

Graphical Abstract

[1]
Jaiswal P, Gidwani B, Vyas A. Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol 2016; 44: 27-40.
[2]
Müller RH, Shegokar R, Keck CM. 20 Years of lipid nanoparticles (SLN & NLCSS). Present state of development & industrial applications. Curr Drug Discov Technol 2011; 8: 207-27.
[3]
Ezzati J, Dolatabadi N, Omidi Y. Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems. Trac-Trend Anal Chem 2016; 77: 100-8.
[4]
Selvamuthukumar S, Velmurugan R. Nanostructured lipid carriers : A potential drug carrier for cancer chemotherapy. Lipids Health Dis 2012.
[http://dx.doi.org/10.1186/1476-511X-11-159]
[5]
Mudshinge SR, Deore AB, Patil S, Bhalgat CM. Nanoparticles: Emerging carriers for drug delivery. Saudi Pharm J 2011; 19(3): 129-41.
[http://dx.doi.org/10.1016/j.jsps.2011.04.001] [PMID: 23960751]
[6]
Ghate MV, Lewis SA, Prabhu P, Dubey A, Patel N. Nanostructured lipid carriers for the topical delivery of tretinoin. Eur J Pharm Biopharm 2016; 108: 253-61.
[7]
Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: Structure, preparation and application. Adv Pharm Bull 2015; 5(3): 305-13.
[http://dx.doi.org/10.15171/apb.2015.043 ] [PMID: 26504751]
[8]
Babazadeh A, Ghanbarzadeh B, Hamishehkar H. Formulation of food grade nanostructured lipid carrier (NLC) for potential applications in medicinal-functional foods. J Drug Deliv Sci Technol 2017; 39: 50-8.
[http://dx.doi.org/10.1016/j.jddst.2017.03.001]
[9]
Jia L, Zhang D, Li Z, et al. Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies. Colloids Surf B Biointerfaces 2010; 80(2): 213-8.
[http://dx.doi.org/10.1016/j.colsurfb.2010.06.008] [PMID: 20621458]
[10]
Teixeira MC, Carbone C, Souto EB. Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery. Prog Lipid Res 2017; 68: 1-1.
[11]
Obeidat WM, Schwabe K, Müller RH, Keck CM. Preservation of nanostructured lipid carriers (NLC). Eur J Pharm Biopharm 2010; 76(1): 56-67.
[http://dx.doi.org/10.1016/j.ejpb.2010.05.001] [PMID: 20452422]
[12]
Alexandra Branco Rosa N. Development of nanoparticles loaded with bioactive compounds for application as nutraceuticals. Integrated Master in Bioeng 2011.
[13]
Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A. Innovative Food Science and Emerging Technologies. EFFoST. 2013.
[14]
Pardeike J, Hommoss A, Müller RH. Lipid nanoparticles (SLN, NLCSS) in cosmetic and pharmaceutical dermal products 2009; 366: 170-84..
[15]
Joshi M, Pathak S, Sharma S, Patravale V. Design and in vivo pharmacodynamic evaluation of nanostructured lipid carriers for parenteral delivery of artemether: Nanoject. Int J Pharm 2008; 364(1): 119-26.
[http://dx.doi.org/10.1016/j.ijpharm.2008.07.032] [PMID: 18765274]
[16]
Kasongo KWA, Pardeike J, Uller RHM, Walker RB. Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers. J Pharm Sci 2011; 100(12): 5185-96.
[http://dx.doi.org/10.1002/jps.22711]
[17]
Gohla S, Ma K, Muller RH. Solid lipid nanoparticles (SLN) for controlled drug delivery ± a review of the state of the art. Eur J Pharm Biopharm 2000; 50: 161-77.
[18]
Fang C, Al-suwayeh S.A, Fang J. Nanostructured Lipid Carriers (NLCSSs) for Drug Delivery and Targeting 2013; 1: 41-55..
[19]
Ribeiro LNM, Breitkreitz MC, Guilherme VA, Gustavo HR, Couto VM, Castro SR, et al. European journal of pharmaceutical sciences natural lipids-based NLCSS containing lidocaine : from pre-formulation to in vivo studies. Eur J Pharm Sci 2017; 106(May): 102-12.
[http://dx.doi.org/10.1016/j.ejps.2017.05.060] [PMID: 28558981]
[20]
Poonia N, Kharb R, Lather V, Pandita D. Nanostructured lipid carriers : versatile oral delivery vehicle. Future Sci OA 2016.
[http://dx.doi.org/10.4155/fsoa-2016-0030]
[21]
Helgason T, Awad TS, Kristbergsson K, et al. Impact of surfactant properties on oxidative stability of β - Carotene encapsulated within solid lipid nanoparticles. J Agric Food Chem 2009; 57: 8033-40.
[22]
Hejri A, Khosravi A, Gharanjig K, Hejazi M. Optimisation of the formulation of β-carotene loaded nanostructured lipid carriers prepared by solvent diffusion method. Food Chem 2013; 141(1): 117-23.
[http://dx.doi.org/10.1016/j.foodchem.2013.02.080] [PMID: 23768336]
[23]
Negi LM, Jaggi M, Talegaonkar S. Development of protocol for screening the formulation components and the assessment of common quality problems of nano-structured lipid carriers. Int J Pharm 2014; 461(1-2): 403-10.
[http://dx.doi.org/10.1016/j.ijpharm.2013.12.006] [PMID: 24345574]
[24]
Singh S, Singh M, Tripathi CB, Arya M, Saraf SA. Development and evaluation of ultra-small nanostructured lipid carriers : novel topical delivery system for athlete’s foot. Drug Deliv Trans 2016; 6: 38-47.
[25]
Khan S, Shaharyar M, Fazil M, Baboota S, Ali J. Tacrolimus-loaded nanostructured lipid carriers for oral delivery - Optimization of production and characterization. Eur J Pharm Biopharm 2016; 108: 277-88.
[http://dx.doi.org/10.1016/j.ejpb.2016.07.017] [PMID: 27449630]
[26]
Khan S, Baboota S, Ali J, Khan S, Narang RS, Narang JK. Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs. Int J Pharm Investig 2015; 5(4): 182-91.
[http://dx.doi.org/10.4103/2230-973X.167661] [PMID: 26682188]
[27]
Zirak MB, Pezeshki A. Effect of surfactant concentration on the particle size, stability and potential zeta of beta carotene nano lipid carrier. Int J Curr Microbiol Appl Sci 2015; 4(9): 924-32.
[28]
Han F, Li S, Yin R, Liu H, Xu L. Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system: Nanostructured lipid carriers. Colloids Surf A Physicochem Eng Asp 2008; 315(1-3): 210-6.
[http://dx.doi.org/10.1016/j.colsurfa.2007.08.005]
[29]
Iqbal A, Sahni JK, Baboota S, et al. Nanostructured lipid carriers system : Recent advances in drug delivery. J Drug Target 2012; 20: 813-30.
[30]
Mehnert W, Mader K. Solid lipid nanoparticles Production, characterization and applications. Adv Drug Deliv Rev 2001; 47: 165-96.
[http://dx.doi.org/10.1016/S0169-409X(01)00105-3]
[31]
Svilenov H, Tzachev C. Solid lipid nanoparticles - A promising drug delivery system outline. Nanomed pp.187-237..
[32]
Mu A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery - Drug release and release mechanism 1998; 45: 149-55..
[33]
Severino P, Santana MH, Souto EB, Souto EB. Optimizing SLN and NLC by 2(2) full factorial design: effect of homogenization technique. Mater Sci Eng C 2012; 32(6): 1375-9.
[http://dx.doi.org/10.1016/j.msec.2012.04.017] [PMID: 24364934]
[34]
Uner M. Preparation, characterization and physicochemical properties of Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLCSS): Their benefits as colloidal drug carrier systems 2006; 61: 375-86..
[35]
Nastruzzi C. Lipospheres in Drug Targets and Delivery Approaches, Methods, and Applications. CRC Press 2004.
[36]
Mizushima Y. Inventor: Maria R. Gasco, Lungo Po Antonelli, 207-10153 Torino, Italy. Method for producing solid lipid microspheres having a narrow size distribution. United States Patent. 5250236. 1993.
[37]
Jintapattanakit A. Preparation of nanoemulsions by phase inversion temperature (PIT) method 2018; 45(1): 1-12..
[38]
Jaiswal J, Kumar S, Kreuter J. Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process 2004; 96: 169-78..
[http://dx.doi.org/10.1016/j.jconrel.2004.01.017]
[39]
Trotta M, Cavalli R, Carlotti ME, Battaglia L, Debernardi F. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion - diffusion technique 2005; 288: 281-8..
[40]
Schubert MA, Mu CC. Solvent injection as a new approach for manufacturing lipid nanoparticles - evaluation of the method and process parameters 2003; 55: 125-31..
[41]
Reithmeier H, Herrmann J, Gopferich A. Lipid microparticles as a parenteral controlled release device for peptides 2001; 73: 339-50..
[http://dx.doi.org/10.1016/S0168-3659(01)00354-6]
[42]
Charcosset C, El-harati A, Fessi H. Preparation of solid lipid nanoparticles using a membrane contactor 2005; 108: 112-20..
[http://dx.doi.org/10.1016/j.jconrel.2005.07.023]
[43]
Mozafari MR, Danaei M, Javanmard R, Raji M, Maherani B. Nanoscale lipidic carrier systems : Importance of Preparation Method and Solvents Nanoscale Lipidic Carrier Systems : Importance of Preparation Method and Solvents. GJN 2017..
[44]
Ganesan P, Narayanasamy D. Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery. Sustain Chem Pharm 2017; 6: 37-56.
[http://dx.doi.org/10.1016/j.scp.2017.07.002]
[45]
Lakshmi P, Kumar GA. Nanosuspension Technology. A review. Int J Pharm Pharm 2010; 2: 35-40.
[46]
Caputo F, Clogston J, Calzolai L, Rösslein M, Prina- Mello A. Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL. A step by step approach combining orthogonal measurements with increasing complexity. J Control Release 2019; 299(299): 31-43..
[PMID: 30797868] [http://dx.doi.org/10.1016/j.jconrel.2019.02.030]
[47]
McClements DJ, Rao J. Food-grade nanoemulsions: Formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr 2011; 51(4): 285-330.
[48]
Saupe A, Gordon KC, Rades T. Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL A step by step approach combining orthogonal measurements with increasing complexity. J Control Release 2006; 229: 31-43.
[http://dx.doi.org/10.1016/j.ijpharm.2006.01.022]
[49]
Forest V, Pourchez J. Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: A too simplistic explanation that does not take into account the nanoparticle protein corona. Mater Sci Eng C 2017; 70(Pt 1): 889-96.
[http://dx.doi.org/10.1016/j.msec.2016.09.016] [PMID: 27770966]
[50]
Patil S, Sandbergb A, Heckertc E. William Selfc, Seala S. Protein adsorption and cellular uptake of cerium oxide.pdf. Biomaterials 2007; 28(31): 4600-7.
[http://dx.doi.org/10.1016/j.biomaterials.2007.07.029] [PMID: 17675227]
[51]
Honary S, Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems - A review (Part 2). Trop J Pharm Res 2013; 12(2): 265-73.
[52]
Gaikwad VL, Choudhari PB, Bhatia NM, Bhatia MS. Characterization of pharmaceutical nanocarriers: In vitro and in vivo studies Nanomaterials for Drug Delivery and Therapy. Elsevier Inc 2019; pp. 33-58.
[53]
Beloqui A, Solinís MÁ, Rodríguez-Gascón A, Almeida AJ, Préat V. Nanostructured lipid carriers: promising drug delivery systems for future clinics. Nanomedicine: Nanotechnology, Biology and Medicine 2016; 2(1): 143-61.
[http://dx.doi.org/10.1016/j.nano.2015.09.004] [PMID: 26410277]
[54]
Domingo C, Saurina J. An overview of the analytical characterization of nanostructured drug delivery systems: towards green and sustainable pharmaceuticals: a review. Anal Chim Acta 2012; 744: 8-22.
[http://dx.doi.org/10.1016/j.aca.2012.07.010] [PMID: 22935368]
[55]
Shao P, Xuan S, Wu W, Qu L. Encapsulation efficiency and controlled release of Ganoderma lucidum polysaccharide microcapsules by spray drying using different combinations of wall materials. Int J Biol Macromol 2019; 125: 962-9.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.12.153] [PMID: 30572060]
[56]
Liu R, Wang S, Sun L, et al. Journal of drug delivery science and technology A novel cationic nanostructured lipid carrier for improvement of ocular bioavailability : Design, optimization, in vitro and in vivo evaluation. J Drug Deliv Sci Technol 2016; 33: 28-36.
[http://dx.doi.org/10.1016/j.jddst.2016.03.009]
[57]
Üstündağ-Okur N, Homan Gökçe E, İnci Bozbıyık D. Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery : evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis. Expert Opin Drug Deliv 2015; 12: 1791-807.
[58]
Fu T, Yi J, Lv S, Zhang B. Ocular amphotericin B delivery by chitosan-modified nanostructured lipid carriers for fungal keratitis-targeted therapy. J Liposome Res 2017; 27(3): 228-33.
[59]
Yu Y, Feng R, Li J, et al. A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform. Asian J Pharm Sci 2018; 14: 423-34.
[60]
Mo Z, Ban J, Zhang Y, et al. Nanostructured lipid carriers-based thermosensitive eye drops for enhanced, sustained delivery of dexamethasone. Nanomedicine (Lond) 2018; 13(11): 1239-53.
[http://dx.doi.org/10.2217/nnm-2017-0318] [PMID: 29949466]
[61]
Sharif Makhmal Zadeh B, Niro H, Rahim F, Esfahani G. Ocular delivery system for propranolol hydrochloride based on nanostructured lipid carrier. Sci Pharm 2018; 86(2)E16
[http://dx.doi.org/10.3390/scipharm86020016] [PMID: 29677103]
[62]
Baig MS, Owida H, Njoroge W. Siddiqui A ur R, Yang Y. Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. J Drug Deliv Sci Technol 2020; 55101496
[http://dx.doi.org/10.1016/j.jddst.2019.101496]
[63]
Tan G, Li J, Song Y, Yu Y, Liu D, Pan W. Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome. Acta Biomater 2019; 99: 350-62.
[http://dx.doi.org/10.1016/j.actbio.2019.08.035] [PMID: 31449929]
[64]
Puglia C, Santonocito D, Ostacolo C, et al. Ocular formulation based on palmitoylethanolamide-loaded nanostructured lipid carriers: Technological and pharmacological profile. Nanomaterials (Basel) 2020; 10(2)E287
[http://dx.doi.org/10.3390/nano10020287] [PMID: 32046269]
[65]
Gade S, Patel KK, Gupta C, et al. An ex vivo evaluation of moxifloxacin nanostructured lipid carrier enriched in situ gel for transcorneal permeation on goat cornea. J Pharm Sci 2019; 108(9): 2905-16.
[http://dx.doi.org/10.1016/j.xphs.2019.04.005] [PMID: 30978345]
[66]
Moreno-Sastre M, Pastor M, Esquisabel A, et al. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm 2016; 498(1-2): 263-73.
[http://dx.doi.org/10.1016/j.ijpharm.2015.12.028] [PMID: 26705155]
[67]
Patil-gadhe A, Kyadarkunte A, Patole M, Pokharkar V. European Journal of Pharmaceutics and Biopharmaceutics Montelukast-loaded nanostructured lipid carriers : Part II Pulmonary drug delivery and in vitro - in vivo aerosol performance. Eur J Pharm Biopharm 2014; 88(1): 169-77.
[http://dx.doi.org/10.1016/j.ejpb.2014.07.007] [PMID: 25078860]
[68]
Patil-Gadhe A, Pokharkar V. Pulmonary targeting potential of rosuvastatin loaded nanostructured lipid carrier: Optimization by factorial design. Int J Pharm 2016; 501(1-2): 199-210.
[http://dx.doi.org/10.1016/j.ijpharm.2016.01.080] [PMID: 26844785]
[69]
Kaur P, Garg T, Rath G, Murthy RSR, Goyal AK. Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design. Drug Deliv 2016; 23(6): 1912-25.
[PMID: 25544602]
[70]
Shao Z, Shao J, Tan B, et al. Targeted lung cancer therapy: preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA. Int J Nanomedicine 2015; 10: 1223-33.
[http://dx.doi.org/10.2147/IJN.S77837 ] [PMID: 25709444]
[71]
Garbuzenko OB, Kbah N, Kuzmov A, Pogrebnyak N, Pozharov V, Minko T. Inhalation treatment of cystic fibrosis with lumacaftor and ivacaftor co-delivered by nanostructured lipid carriers. J Control Release 2019; 296(296): 225-31.
[http://dx.doi.org/10.1016/j.jconrel.2019.01.025] [PMID: 30677435]
[72]
Sharma K, Hallan SS, Lal B, Bhardwaj A, Mishra N. Development and characterization of floating spheroids of atorvastatin calcium loaded NLCSS for enhancement of oral bioavailability. Artif Cells Nanomed Biotechnol 2016; 44: 1448-56.
[http://dx.doi.org/10.3109/21691401.2015.1041637] [PMID: 25960179]
[73]
Godugu C, Doddapaneni R, Safe SH, Singh M. Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer. Eur J Pharm Biopharm 2016; 108: 168-79.
[http://dx.doi.org/10.1016/j.ejpb.2016.08.006] [PMID: 27586082]
[74]
Aljaeid BM, Hosny KM. Fabrication and evaluation of Phytomenadione as a nanostructure lipid carrier for enhancement of bioavailability. Pharmaceutical development and technology 2018; 23(4): 382-6.
[75]
Zhou X, Zhang X, Ye Y, et al. Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption. Int J Pharm 2015; 479(2): 391-8.
[http://dx.doi.org/10.1016/j.ijpharm.2014.12.068] [PMID: 25556104]
[76]
Das S, Ghosh S, De AK, Bera T. Oral delivery of ursolic acid-loaded nanostructured lipid carrier coated with chitosan oligosaccharides: Development, characterization, in vitro and in vivo assessment for the therapy of leishmaniasis. Int J Biol Macromol 2017; 102: 996-1008.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.04.098] [PMID: 28465178]
[77]
Hua Y, Li W, Cheng Z, et al. Solidification of nanostructured lipid carriers loaded testosterone undecanoate: In Vivo and In Vitro Study. Drug Res (Stuttg) 2018; 68(8): 457-64.
[http://dx.doi.org/10.1055/a-0573-9132 ] [PMID: 29589341]
[78]
Dong Z, Iqbal S, Zhao Z. Preparation of ergosterol-loaded nanostructured lipid carriers for enhancing oral bioavailability and antidiabetic nephropathy effects. AAPS PharmSciTech 2020; 21(2): 64.
[http://dx.doi.org/10.1208/s12249-019-1597-3] [PMID: 31932990]
[79]
Son GH, Na YG, Huh HW, et al. Systemic design and evaluation of ticagrelor-loaded nanostructured lipid carriers for enhancing bioavailability and antiplatelet activity. Pharmaceutics 2019; 11(5)E222
[http://dx.doi.org/10.3390/pharmaceutics11050222] [PMID: 31071977]
[80]
Mathur P, Sharma S, Rawal S, Patel B, Patel MM. Fabrication, optimization, and in vitro evaluation of docetaxel-loaded nanostructured lipid carriers for improved anticancer activity. J Liposome Res 2020; 30: 182-96.
[http://dx.doi.org/10.1080/08982104.2019.1614055] [PMID: 31060404]
[81]
El Assasy AEI, Younes NF, Makhlouf AIA. Enhanced oral absorption of amisulpride via a nanostructured lipid carrier-based capsules: Development, optimization applying the desirability function approach and in vivo pharmacokinetic study. AAPS PharmSciTech 2019; 20(2): 82.
[http://dx.doi.org/10.1208/s12249-018-1283-x] [PMID: 30652198]
[82]
Prabhu P, Suryavanshi S, Pathak S, Patra A, Sharma S, Patravale V. Nanostructured lipid carriers of artemether-lumefantrine combination for intravenous therapy of cerebral malaria. Int J Pharm 2016; 513(1-2): 504-17.
[http://dx.doi.org/10.1016/j.ijpharm.2016.09.008] [PMID: 27596113]
[83]
Liu X, Zhang Z, Jiang Y, et al. Novel PEG-grafted nanostructured lipid carrier for systematic delivery of a poorly soluble anti- leukemia agent Tamibarotene : characterization and evaluation. Drug Deliv 2015; 22: 223-9.
[84]
Erasmus JH, Khandhar AP, Guderian J, et al. a nanostructured lipid carrier for delivery of a replicating viral RNA provides single, low-dose protection against zika. Mol Ther 2018; 26(10): 2507-22.
[http://dx.doi.org/10.1016/j.ymthe.2018.07.010] [PMID: 30078765]
[85]
Olerile LD, Liu Y, Zhang B, et al. Near-infrared mediated quantum dots and paclitaxel co-loaded nanostructured lipid carriers for cancer theragnostic. Colloids Surf B Biointerfaces 2017; 150: 121-30.
[http://dx.doi.org/10.1016/j.colsurfb.2016.11.032] [PMID: 27907859]
[86]
Meng F, Asghar S, Gao S, et al. A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer’s disease. Colloids Surf B Biointerfaces 2015; 134: 88-97.
[http://dx.doi.org/10.1016/j.colsurfb.2015.06.025] [PMID: 26162977]
[87]
Garcia-orue I, Gainza G, Girbau C, et al. European Journal of Pharmaceutics and Biopharmaceutics LL37 loaded nanostructured lipid carriers (NLCSS): A new strategy for the topical treatment of chronic wounds. Eur J Pharm Biopharm 2016; 108: 310-6.
[http://dx.doi.org/10.1016/j.ejpb.2016.04.006] [PMID: 27080206]
[88]
Malik DS, Kaur G. Journal of drug delivery science and technology nanostructured gel for topical delivery of azelaic acid : Designing, characterization, and in-vitro evaluation. J Drug Deliv Sci Technol 2018; 47(April): 123-36.
[http://dx.doi.org/10.1016/j.jddst.2018.07.008]
[89]
Chen P, Zhang H, Cheng S, Zhai G, Shen C. Colloids and surfaces A : Physicochemical and engineering aspects development of curcumin loaded nanostructured lipid carrier based thermosensitive in situ gel for dermal delivery. Colloids Surf A Physicochem Eng Asp 2016; 506: 356-62.
[http://dx.doi.org/10.1016/j.colsurfa.2016.06.054]
[90]
Yue Y, Zhao D, Yin Q. Biomedicine & Pharmacotherapy Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery : In vitro and in vivo anesthesia evaluation. Biomed Pharmacother 2018; 98(89): 813-20.
[http://dx.doi.org/10.1016/j.biopha.2017.12.103] [PMID: 29571251]
[91]
Orgul D, Eroglu H, Hekimoglu S. Journal of drug delivery science and technology formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds. J Drug Deliv Sci Technol 2017; 41: 280-92.
[http://dx.doi.org/10.1016/j.jddst.2017.08.001]
[92]
Zhao S, Minh LV, Garamus VM, et al. Doxorubicin hydrochloride-oleic acid conjugate loaded nanostructured lipid carriers for tumor specific drug release. Colloids Surf B Biointerfaces 2016; 145: 95-103.
[93]
Cheng-ying S, Ling DAI, Bao-de S, et al. Nanostructured lipid carrier based topical gel of Ganoderma Triterpenoids for frostbite treatment 2015; 13(6): 454- 60..
[94]
Nahak P, Gajbhiye RL, Karmakar G, et al. Orcinol glucoside loaded polymer - lipid hybrid nanostructured lipid carriers: Potential cytotoxic agents against gastric, colon and hepatoma carcinoma cell lines. Pharm Res 2018; 35(10): 198.
[http://dx.doi.org/10.1007/s11095-018-2469-3] [PMID: 30151753]
[95]
Nitthikan N, Leelapornpisid P, Natakankitkul S, et al. Improvement of stability and transdermal delivery of bioactive compounds in green robusta coffee beans extract loaded nanostructured lipid carriers. J Nanotechnol 2018; 20187865024
[96]
Ong YS, Saiful Yazan L, Ng WK, et al. Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice. Nanomedicine (Lond) 2018; 13(13): 1567-82.
[http://dx.doi.org/10.2217/nnm-2017-0322 ] [PMID: 30028248]
[97]
Yuan X, Fei F, Sun H, et al. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine 2018; 13: 2265-74.
[http://dx.doi.org/10.2147/IJN.S159789 ] [PMID: 29695905]
[98]
Lacatusu I, Badea G, Popescu M, et al. Marigold extract, azelaic acid and black caraway oil into lipid nanocarriers provides a strong anti-inflammatory effect in vivo. Ind Crops Prod 2017; 109: 141-50.
[http://dx.doi.org/10.1016/j.indcrop.2017.08.030]
[99]
Medina-Alarcón KP, Singulani JL, Voltan AR, et al. Alkyl protocatechuate-loaded nanostructured lipid systems as a treatment strategy for Paracoccidioides brasiliensis and paracoccidioides lutzii in vitro. Front Microbiol 2017; 8: 1048.
[http://dx.doi.org/10.3389/fmicb.2017.01048] [PMID: 28659880]
[100]
Khurana RK, Bansal AK, Beg S, et al. Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation. Int J Pharm 2017; 518(1-2): 289-306.
[http://dx.doi.org/10.1016/j.ijpharm.2016.12.044] [PMID: 28025072]
[101]
Hatem S, Nasr M, Moftah NH, Ragai MH, Geneidi AS, Elkheshen SA. Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils. Expert Opin Drug Deliv 2018; 15(10): 927-35.
[http://dx.doi.org/10.1080/17425247.2018.1517740] [PMID: 30169980]
[102]
Kamel R, Abbas H, Fayez A. Diosmin/essential oil combination for dermal photo-protection using a lipoid colloidal carrier. J Photochem Photobiol B 2017; 170: 49-57.
[http://dx.doi.org/10.1016/j.jphotobiol.2017.03.019] [PMID: 28390258]
[103]
Lacatusu I, Arsenie LV, Badea G, Popa O, Oprea O, Badea N. New cosmetic formulations with broad photoprotective and antioxidative activities designed by amaranth and pumpkin seed oils nanocarriers. Ind Crops Prod 2018; 123: 424-33.
[http://dx.doi.org/10.1016/j.indcrop.2018.06.083 ]

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