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New Emirates Medical Journal

Editor-in-Chief
ISSN (Online): 0250-6882

Research Article

Trends of Mortalities and Morbidities due to COVID-19, from Explosiveness to Aggressiveness, Gaps in System Response, and Transmission Chain

Author(s): Hamid Yahya Hussain, Nezar Ahmed Salim*, Bushra Baderkhan, Mohamed Hamid, Abdulla Hamid, Fouad Hussein Chehab, Khaled H. A. Al Qawasmeh and Mohammed Tuffaha

Volume 2, Issue 1, 2021

Published on: 15 June, 2020

Page: [20 - 24] Pages: 5

DOI: 10.2174/0250688201999200615180438

open_access

Abstract

Background: Due to the high prevalence and wide distribution of coronaviruses, their large genetic diversity, frequent recombination of their genomes, and increasing human-animal interface activities, novel coronaviruses are likely to emerge periodically in humans owing to frequent cross-species infections and occasional spillover event.

Objective: The aim of this research is to study the short-term morbidities, mortalities and trends of international spread of the COVID-19 outbreak. In addition, to study the explosiveness and aggressiveness of the outbreak and the gaps in response.

Methodology: Outbreak events were observed and followed up over two months. This study used daily statistical reports issued by the World Health Organization, as well as data from different national authorities, regarding mortalities and morbidities from all over the world, with a specific focus on Chinese statistics as the main source of the outbreak.

Results: The current study showed that the number of confirmed COVID-19 infected cases started with 41 cases in early January 2020. The number of cases with COVID-19 kept rising to reach 128000 on March 12, 2020. Moreover, the current study has revealed that the number of deaths was only (1) case in early January 2020 and increased to 25 deaths on January 23, and end up with 170 deaths by the end of January. Deaths have dramatically increased to reach 2462 on Feb 23 and 4717 on March 12. In regards to the geographical spread of the COVID-19 infection outbreak, the number of affected countries increased to 100 by mid- March 2020. The number of fatality cases was 0.0368, compared to 0.533 in recovered cases within two months.

Conclusion: The natural history and course of the current outbreak revealed a highly explosive nature linked to considerable aggressiveness in terms of complications and mortalities, within only two months, and spread to 100 countries worldwide with 80000 cases within only two months. The study forecasted that the peak of the outbreak is not yet attained, and events that are more dramatic may occur worldwide.

Keywords: COVID-19, Mortality, Morbidity, Explosiveness, Aggressiveness, Transmission chain.

[1]
Richman DD, Whitley RJ, Hayden FG. Clinical virology 4th Washington : ASM Press 2016 Google Scholar.
[2]
Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348(20): 1953-66.
[http://dx.doi.org/10.1056/NEJMoa030781] [PMID: 12690092]
[3]
Kuiken T, Fouchier RAM, Schutten M. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003; 362(9380): 263-70.
[http://dx.doi.org/10.1016/S0140-6736(03)13967-0] [PMID: 12892955]
[4]
Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348(20): 1967-76.
[http://dx.doi.org/10.1056/NEJMoa030747] [PMID: 12690091]
[5]
de Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol 2013; 87(14): 7790-2.
[http://dx.doi.org/10.1128/JVI.01244-13] [PMID: 23678167]
[6]
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus ADME, Fouchier RAM. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367(19): 1814-20.
[http://dx.doi.org/10.1056/NEJMoa1211721] [PMID: 23075143]
[7]
WHO Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. https://www.who.int/csr/sars/country/table2004_04_21/en/ Accessed 19th Jan 2020,Google Scholar
[8]
WHO Middle East respiratory syndrome coronavirus (MERS-CoV) . http://www.who.int/emergencies/mers-cov/en/ (November, 2019), Accessed 19th Jan 2020, Google Scholar
[9]
WHO Novel coronavirus – China. http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/ (Jan 12, 2020), Accessed 19th Jan 2020, Google Scholar
[10]
WHO Novel coronavirus – Thailand (ex-China). http://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand/en/ (Jan 14, 2020), Accessed 19th Jan 2020,Google Scholar
[11]
WHO Novel coronavirus – Japan (ex-China),. http://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/ (Jan 17, 2020), Accessed 19th Jan 2020,Google Scholar
[12]
WHO Novel coronavirus – Republic of Korea (ex-China), . http://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-korea-ex-china/en/ (Jan 21, 2020), Accessed 23rd Jan 2020,Google Scholar
[13]
CDC First travel-related case of 2019 novel coronavirus detected in United States. https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html (Jan 21, 2020), Accessed 23rd Jan 2020, Google Scholar
[14]
Tan W, Zhao X, Ma X, et al. A novel coronavirus genome identified in a cluster of pneumonia cases — Wuhan, China 2019−2020. http://weekly.chinacdc.cn/en/article/id/a3907201-f64f-4154-a19e-4253b453d10c Accessed 23rd Jan 2020,Google Scholar
[15]
Centre for Health Protection of the Hong Kong Special Administrative Region Government CHP closely monitors cluster of pneumonia cases on Mainland. https://www.info.gov.hk/gia/general/201912/31/P2019123100667.htm2019. (Dec 31, 2019), Accessed 21st Jan 2020, Google Scholar
[16]
Centre for Health Protection of the Hong Kong Special Administrative Region Government CHP provides further information on cluster of pneumonia cases in Wuhan. https://www.info.gov.hk/gia/general/202001/12/P2020011200710.htm (Jan 12, 2020), Accessed 21st Jan 2020, Google Scholar
[17]
Juan D. Wuhan wet market closes amid pneumonia outbreak, ChinaDaily (Jan 1, 2020) https://www.chinadaily.com.cn/a/202001/01/WS5e0c6a49a310cf3e35581e30.html Accessed 21st Jan 2020, Google Scholar
[18]
Cohen J. Chinese researchers reveal draft genome of virus implicated in Wuhan pneumonia outbreak American Association for the Advancement of Science, Washington, DC (Jan 11, 2020) . https://www.sciencemag.org/news/2020/01/chinese-researchers-reveal-draft-genome-virus-implicated-wuhan-pneumonia-outbreakAccessed 21st Jan 2020, Google Scholar5
[19]
To KK, Chan KH, Li IW, et al. Viral load in patients infected with pandemic H1N1 2009 influenza A virus Med Virol. 2010; 82: pp. 1-7. CrossRefView Record in ScopusGoogle Scholar
[20]
To KKW, Yip CCY, Lai CYW, et al. Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study. Clin Microbiol Infect 2019; 25(3): 372-8.
[http://dx.doi.org/10.1016/j.cmi.2018.06.009] [PMID: 29906597]
[21]
Chan KH, To KKW, Li PTW, et al. Evaluation of NxTAG Respiratory pathogen panel and comparison with xTAG respiratory viral panel fast v2 and film array respiratory panel for detecting respiratory pathogens in nasopharyngeal aspirates and swine/avian-origin influenza A subtypes in culture isolates. Adv Virol 2017; 2017: 1324276.
[http://dx.doi.org/10.1155/2017/1324276] [PMID: 28947901]
[22]
Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361(9366): 1319-25.
[http://dx.doi.org/10.1016/S0140-6736(03)13077-2] [PMID: 12711465]
[23]
Chan JF, Zhang AJ, Chan CC, et al. Zika virus infection in dexamethasone-immunosuppressed mice demonstrating disseminated infection with multi-organ involvement including orchitis effectively treated by recombinant type I interferons. EBioMedicine 2016; 14: 112-22.
[http://dx.doi.org/10.1016/j.ebiom.2016.11.017] [PMID: 27884655]
[24]
To KKW, Chan WM, Li KSM, et al. High prevalence of four novel astrovirus genotype species indentified from rodents in China. J Gen.Virol 2017; 98(5): 1004-15..
[25]
Woo PC, Lau SK, Teng JL, et al. Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses. Virology 2014; 471-473: 117-25.
[http://dx.doi.org/10.1016/j.virol.2014.09.020] [PMID: 25461537]
[26]
WHO Novel coronavirus health-topics/coronavirus. https://www.who.int/health-topics/coronavirus#tab=tab_1 Accessed 19th Jan 2020, Google Scholar

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