One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylates Under Microwave Irradiation

Title:One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylates Under Microwave Irradiation

Volume: 1 Issue: 2

Author(s): Rajni Khajuria and Kamal K. Kapoor

Affiliation:

Keywords: 1, 3-disubstituted propen-2-ones, cascade, diethylamine, ethyl 3, 5-disubstituted-1H-pyrrole-2-carboxylates, ethylnitroacetate, Michael-reductive cyclization, MW irradiation, one-pot, solvent-free, triethylphosphite.

Abstract: An efficient, one-pot, solvent-free synthesis of ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylate is achieved by a reaction of 1,3-disubstituted propen-2-one and ethylnitroacetate, in presence of diethylamine (Et₂NH) and triethylphosphite (P(OEt)₃) under microwave (MW) irradiation via cascade Michael-reductive cyclization. The mechanistic outcome of the reaction has also been described. This protocol establishes an easy access to disubstituted-1H-pyrrole-2- carboxylates in one pot.

Cite this article as:

Khajuria Rajni and Kapoor K. Kamal, One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylates Under Microwave Irradiation, Current Microwave Chemistry 2014; 1 (2) . https://dx.doi.org/10.2174/2213335601666140620221842