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Current Neuropharmacology

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General Review Article

Antiepileptogenic Effect of Retinoic Acid

Author(s): Artemio Rosiles-Abonce, Carmen Rubio, Elisa Taddei, Dulce Rosiles and Moisés Rubio-Osornio*

Volume 19, Issue 3, 2021

Published on: 29 April, 2020

Page: [383 - 391] Pages: 9

DOI: 10.2174/1570159X18666200429232104

Price: $65

Abstract

Retinoic acid, a metabolite of vitamin A, acts through either genomic or nongenomic actions. The genomic action of retinoids exerts effects on gene transcription through interaction with retinoid receptors such as retinoic acid receptors (RARα, β, and γ) and retinoid X receptors (RXRα, β, and γ) that are primarily concentrated in the amygdala, pre-frontal cortex, and hippocampal areas in the brain. In response to retinoid binding, RAR/RXR heterodimers undergo major conformational changes and orchestrate the transcription of specific gene networks. Previous experimental studies have reported that retinoic acid exerts an antiepileptogenic effect through diverse mechanisms, including the modulation of gap junctions, neurotransmitters, long-term potentiation, calcium channels and some genes. To our knowledge, there are no previous or current clinical trials evaluating the use of retinoic acid for seizure control.

Keywords: Epilepsy, seizures, antiepileptic, retinoic acid, genes, retinoids.

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