Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Research Article

Far Infrared Technology (FIT) Therapy Patches, Protects from Inflammation, Oxidative Stress and Promotes Cellular Vitality

Author(s): Donatella Pastore, Francesca Pacifici, Giampaolo Ciao, Valentina Bedin, Guido Pasquantonio and David Della-Morte*

Volume 26, Issue 34, 2020

Page: [4323 - 4329] Pages: 7

DOI: 10.2174/1381612826666200427112023

Price: $65

Abstract

Background: It is known from the most recent literature that far-infrared (FIR) radiations promote a broad spectrum of therapeutic benefits for cells and tissues.

Objective: To identify molecular mechanisms by which FIT patches, as a far infrared technology, protects against damage caused by inflammatory process and oxidative stress.

Methods: Endothelial cells (HUVEC, Human Umbilical Vein Endothelial Cells) were used as in vitro experimental model. HUVEC were stimulated with a pro-inflammatory cytokine, TNF-α, or hydrogen peroxide (H2O2) to induce oxidative stress. As markers of inflammation were evaluated: VCAM1 (Vascular Cell Adhesion Molecule 1), ICAM1 (Intercellular Adhesion Molecule 1) and E-Selectin by Western Blot analysis. Oxidative stress was assessed by cytofluorimetric analysis. The experiments were performed on control cells (no patch) or in cells treated with the FIT infrared technology applied on the basis of the culture plate.

Results: HUVEC stimulated with TNF-α and treated with FIT patches had significant reduction of the expression of VCAM1, ICAM1 and E-Selectin (p<0.05). HUVEC stimulated with H2O2 and treated with FIT patches were significantly protected from oxidative stress (p <0.01) when compared to control cells. We measured cell viability and proliferation in HUVEC and HEK-293 (Human embryonic kidney cells) cells by MTT assay. HEK-293 and HUVEC treated with FIT patches showed a significantly higher percentage of basal vitality compared to control cells (p<0.0001 for HEK-293, p<0.05 for HUVEC).

Conclusion: FIT therapy patches - infrared technology, through these protective mechanisms, could be used in all pathologies where an increase in inflammation, oxidative stress and degenerative state are present.

Keywords: Infrared technology, patches, ROS, inflammation, oxidative stress, chronic diseases.

« Previous Next »
[1]
Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8(4): 253-62.
[http://dx.doi.org/10.1038/nrg2045] [PMID: 17363974]
[2]
Kunnumakkara AB, Sailo BL, Banik K, et al. Chronic diseases, inflammation, and spices: How are they linked? J Transl Med 2018; 16(1): 14.
[http://dx.doi.org/10.1186/s12967-018-1381-2] [PMID: 29370858]
[3]
Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging 2018; 13: 757-72.
[http://dx.doi.org/10.2147/CIA.S158513] [PMID: 29731617]
[4]
Cho S, Shin MH, Kim YK, et al. Effects of infrared radiation and heat on human skin aging in vivo. J Investig Dermatol Symp Proc 2009; 14(1): 15-9.
[http://dx.doi.org/10.1038/jidsymp.2009.7] [PMID: 19675547]
[5]
Lin CC, Chang CF, Lai MY, Chen TW, Lee PC, Yang WC. Far-infrared therapy: a novel treatment to improve access blood flow and unassisted patency of arteriovenous fistula in hemodialysis patients. J Am Soc Nephrol 2007; 18(3): 985-92.
[http://dx.doi.org/10.1681/ASN.2006050534] [PMID: 17267744]
[6]
Lai YT, Chan HL, Lin SH, et al. Far-infrared ray patches relieve pain and improve skin sensitivity in myofascial pain syndrome: A double-blind randomized controlled study. Complement Ther Med 2017; 35: 127-32.
[http://dx.doi.org/10.1016/j.ctim.2017.10.007] [PMID: 29154057]
[7]
Huang PH, Chen JW, Lin CP, et al. Far infra-red therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. Cardiovasc Diabetol 2012; 11: 99.
[http://dx.doi.org/10.1186/1475-2840-11-99] [PMID: 22894755]
[8]
Pastore D, Della-Morte D, Coppola A, et al. SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α. Cell Death Dis 2015; 6: e1890.
[http://dx.doi.org/10.1038/cddis.2015.232] [PMID: 26379195]
[9]
Chen L, Deng H, Cui H, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 2017; 9(6): 7204-18.
[PMID: 29467962]
[10]
Steven S, Frenis K, Oelze M, et al. Vascular inflammation and oxidative stress: Major triggers for cardiovascular disease. Oxid Med Cell Longev 2019; 2019: 7092151.
[http://dx.doi.org/10.1155/2019/7092151] [PMID: 31341533]
[11]
Shui S, Wang X, Chiang JY, Zheng L. Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review. Exp Biol Med (Maywood) 2015; 240(10): 1257-65.
[http://dx.doi.org/10.1177/1535370215573391] [PMID: 25716016]
[12]
Yu SY, Chiu JH, Yang SD, Hsu YC, Lui WY, Wu CW. Biological effect of far-infrared therapy on increasing skin microcirculation in rats. Photodermatol Photoimmunol Photomed 2006; 22(2): 78-86.
[http://dx.doi.org/10.1111/j.1600-0781.2006.00208.x] [PMID: 16606412]
[13]
Tei C, Horikiri Y, Park JC, et al. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation 1995; 91(10): 2582-90.
[http://dx.doi.org/10.1161/01.CIR.91.10.2582] [PMID: 7743620]
[14]
Ikeda Y, Biro S, Kamogawa Y, et al. Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters. Circ J 2005; 69(6): 722-9.
[http://dx.doi.org/10.1253/circj.69.722] [PMID: 15914953]
[15]
Masuda A, Miyata M, Kihara T, Minagoe S, Tei C. Repeated sauna therapy reduces urinary 8-epi-prostaglandin F(2alpha). Jpn Heart J 2004; 45(2): 297-303.
[http://dx.doi.org/10.1536/jhj.45.297] [PMID: 15090706]
[16]
Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986; 320(6061): 454-6.
[http://dx.doi.org/10.1038/320454a0] [PMID: 3007998]
[17]
Ryotokuji K, Ishimaru K, Kihara K, Namiki Y, Hozumi N. Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus. Laser Ther 2013; 22(3): 209-14.
[http://dx.doi.org/10.5978/islsm.13-OR-18] [PMID: 24204095]
[18]
Lin CC, Liu XM, Peyton K, et al. Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. Arterioscler Thromb Vasc Biol 2008; 28(4): 739-45.
[http://dx.doi.org/10.1161/ATVBAHA.107.160085] [PMID: 18202320]
[19]
Hausswirth C, Louis J, Bieuzen F, et al. Effects of whole-body cryotherapy vs. far-infrared vs. passive modalities on recovery from exercise-induced muscle damage in highly-trained runners. PLoS One 2011; 6(12): e27749.
[http://dx.doi.org/10.1371/journal.pone.0027749] [PMID: 22163272]
[20]
Tsai SR, Hamblin MR. Biological effects and medical applications of infrared radiation. J Photochem Photobiol B 2017; 170: 197-207.
[http://dx.doi.org/10.1016/j.jphotobiol.2017.04.014] [PMID: 28441605]
[21]
Migliario M, Sabbatini M, Mortellaro C, Renò F. Near infrared low-level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways. J Biophotonics 2018; 11(11): e201800025.
[http://dx.doi.org/10.1002/jbio.201800025] [PMID: 29722183]
[22]
Chung J, Lee S. Development of nanofibrous membranes with far-infrared radiation and their antimicrobial properties. Fibers Polym 2014; 15: 1153-9.
[http://dx.doi.org/10.1007/s12221-014-1153-4]
[23]
Khan I, Pathan S, Li XA, et al. Far infrared radiation induces changes in gut microbiota and activates GPCRs in mice. J Adv Res 2019; 22: 145-52.
[http://dx.doi.org/10.1016/j.jare.2019.12.003] [PMID: 31969995]
[24]
Yuan X, Wang L, Bhat OM, Lohner H, Li PL. Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate. Redox Biol 2018; 16: 21-31.
[http://dx.doi.org/10.1016/j.redox.2018.02.007] [PMID: 29475132]
[25]
Vamanu E. Complementary Functional Strategy for Modulation of Human Gut Microbiota. Curr Pharm Des 2018; 24(35): 4144-9.
[http://dx.doi.org/10.2174/1381612824666181001154242] [PMID: 30277147]
[26]
Vamanu E. Polyphenolic nutraceuticals to combat oxidative stress through microbiota modulation. Front Pharmacol 2019; 10: 492.
[http://dx.doi.org/10.3389/fphar.2019.00492] [PMID: 31130865]

Rights & Permissions Print Cite
Article Metrics
14
1
© 2024 Bentham Science Publishers | Privacy Policy