Abstract
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
Keywords: EGFR, HER-1, ERBB-1, Tyrosine kinase, EGF, TGF-α, mAbs, Inhibitors, cancer.
Graphical Abstract
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