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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Review Article

Therapeutic Effects of Curcumin against Bladder Cancer: A Review of Possible Molecular Pathways

Author(s): Milad Ashrafizadeh, Habib Yaribeygi* and Amirhossein Sahebkar*

Volume 20, Issue 6, 2020

Page: [667 - 677] Pages: 11

DOI: 10.2174/1871520620666200203143803

Price: $65

Abstract

There are concerns about the increased incidence of cancer both in developing and developed countries. In spite of recent progress in cancer therapy, this disease is still one of the leading causes of death worldwide. Consequently, there have been rigorous attempts to improve cancer therapy by looking at nature as a rich source of naturally occurring anti-tumor drugs. Curcumin is a well-known plant-derived polyphenol found in turmeric. This compound has numerous pharmacological effects such as antioxidant, anti-inflammatory, antidiabetic and anti-tumor properties. Curcumin is capable of suppressing the growth of a variety of cancer cells including those of bladder cancer. Given the involvement of various signaling pathways such as PI3K, Akt, mTOR and VEGF in the progression and malignancy of bladder cancer, and considering the potential of curcumin in targeting signaling pathways, it seems that curcumin can be considered as a promising candidate in bladder cancer therapy. In the present review, we describe the molecular signaling pathways through which curcumin inhibits invasion and metastasis of bladder cancer cells.

Keywords: Curcumin, bladder cancer, signaling pathway, cancer therapy, herbal medicine, polyphenol.

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