Generic placeholder image

Current Psychiatry Research and Reviews

Editor-in-Chief

ISSN (Print): 2666-0822
ISSN (Online): 2666-0830

Research Article

Post-traumatic Stress Disorder in Heart Failure Patients: A Test of the Cardiac Disease-induced PTSD Hypothesis

Author(s): Phillip J. Tully* and Suzanne M. Cosh

Volume 15, Issue 4, 2019

Page: [290 - 296] Pages: 7

DOI: 10.2174/2666082215666191113121558

Price: $65

Abstract

Background: Post-traumatic stress disorder (PTSD) is prevalent in approximately 12% of patients with cardiovascular disease (CVD) and such patients are at risk of further CVD morbidity and mortality. It is unknown whether CVD patients with cardiac and non-cardiac traumatic events leading to PTSD differ in medical comorbidities and psychiatric vulnerabilities. Our objective was to compare heart failure (HF) patients with cardiac and non-cardiac PTSD.

Methods: A population of HF patients from 3 hospitals underwent a two-step depression and anxiety screening process to identify potential mental health treatment needs. The post-traumatic stress disorder module of the Structured Clinical Interview for DSM-IV Axis-I disorders was used to classify trauma(s) exposure, and other disorders. The patients with PTSD were sub-divided by cardiac related traumas (e.g. myocardial infarction, sudden cardiac arrest) and non-cardiac related traumas (e.g. sexual abuse, interpersonal violence).

Results: 10 patients met criteria for non-cardiac trauma and 18 patients met criteria for cardiacinduced trauma. There were no significant differences in HF aetiology or severity nor cardiac comorbidities. Time since PTSD, onset was significantly longer for those with non-cardiac PTSD. Among psychiatric comorbidities, alcohol and substance abuse disorders, as well as depression were more prevalent in patients with non-cardiac PTSD.

Conclusion: Cardiac related PTSD was associated with less alcohol and substance abuse disorders, and depression by comparison to their non-cardiac induced PTSD counterparts. Ongoing research is required to establish if cardiac-induced PTSD truly reflects a unique subtype of PTSD, and whether there are different treatment needs and therapeutic approaches for this subtype.

Keywords: Post-traumatic stress disorder, depression, anxiety disorder, heart failure, cardiomyopathy, trauma.

Graphical Abstract

[1]
Edmondson D, Kronish IM, Shaffer JA, Falzon L, Burg MM. Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review. Am Heart J 2013; 166(5): 806-14.
[http://dx.doi.org/10.1016/j.ahj.2013.07.031] [PMID: 24176435]
[2]
Edmondson D, Richardson S, Falzon L, Davidson KW, Mills MA, Neria Y. Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review. PLoS One 2012; 7(6) :e38915
[http://dx.doi.org/10.1371/journal.pone.0038915] [PMID: 22745687]
[3]
Edmondson D, Rieckmann N, Shaffer JA, et al. Posttraumatic stress due to an acute coronary syndrome increases risk of 42-month major adverse cardiac events and all-cause mortality. J Psychiatr Res 2011; 45(12): 1621-6.
[http://dx.doi.org/10.1016/j.jpsychires.2011.07.004] [PMID: 21807378]
[4]
Pedersen SS, Middel B, Larsen ML. Posttraumatic stress disorder in first-time myocardial infarction patients. Heart Lung 2003; 32(5): 300-7.
[http://dx.doi.org/10.1016/S0147-9563(03)00097-9] [PMID: 14528187]
[5]
Vilchinsky N, Ginzburg K, Fait K, Foa EB. Cardiac-disease-induced PTSD (CDI-PTSD): A systematic review. Clin Psychol Rev 2017; 55: 92-106.
[http://dx.doi.org/10.1016/j.cpr.2017.04.009] [PMID: 28575815]
[6]
Kessler RC, Aguilar-Gaxiola S, Alonso J, et al. Trauma and PTSD in the WHO World Mental Health Surveys. Eur J Psychotraumatol 2017; 8(5): 1353383-7.
[http://dx.doi.org/10.1080/20008198.2017.1353383]
[7]
Wilson MA, Liberzon I, Lindsey ML, et al. Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure. Stress 2019; 22(22): 530-47.
[http://dx.doi.org/10.1080/10253890.2019.1621283]
[8]
Favaro A, Gerosa G, Caforio AL, et al. Posttraumatic stress disorder and depression in heart transplantation recipients: the relationship with outcome and adherence to medical treatment. Gen Hosp Psychiatry 2011; 33(1): 1-7.
[http://dx.doi.org/10.1016/j.genhosppsych.2010.10.001] [PMID: 21353121]
[9]
Habibović M, Denollet J, Pedersen SS. Posttraumatic stress and anxiety in patients with an implantable cardioverter defibrillator: Trajectories and vulnerability factors. Pacing Clin Electrophysiol 2017; 40(7): 817-23.
[http://dx.doi.org/10.1111/pace.13090] [PMID: 28432794]
[10]
Tully PJ, Winefield HR, Baker RA, et al. Depression, anxiety and major adverse cardiovascular and cerebrovascular events in patients following coronary artery bypass graft surgery: a five year longitudinal cohort study. Biopsychosoc Med 2015; 9: 14.
[http://dx.doi.org/10.1186/s13030-015-0041-5] [PMID: 26019721]
[11]
Presciutti A, Verma J, Pavol M, et al. Posttraumatic stress and depressive symptoms characterize cardiac arrest survivors’ perceived recovery at hospital discharge. Gen Hosp Psychiatry 2018; 53: 108-13.
[http://dx.doi.org/10.1016/j.genhosppsych.2018.02.006] [PMID: 29776732]
[12]
Rich-Edwards JW, Mason S, Rexrode K, et al. Physical and sexual abuse in childhood as predictors of early-onset cardiovascular events in women. Circulation 2012; 126(8): 920-7.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.111.076877] [PMID: 22787111]
[13]
Wright EN, Hanlon A, Lozano A, Teitelman AM. The association between intimate partner violence and 30-year cardiovascular disease risk among young adult women. J Interpers Violence 2018.
[14]
Husain SA, Edmondson D, Kautz M, Umland R, Kronish IM. Posttraumatic stress disorder due to acute cardiac events and aversive cognitions towards cardiovascular medications. J Behav Med 2018; 41(2): 261-8.
[http://dx.doi.org/10.1007/s10865-017-9906-3] [PMID: 29204908]
[15]
Chioncel O, Mebazaa A, Harjola VP, et al. Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC heart failure long-term registry. Eur J Heart Fail 2017; 19(10): 1242-54.
[http://dx.doi.org/10.1002/ejhf.890] [PMID: 28463462]
[16]
Kroenke K, Spitzer RL, Williams JB, Löwe B. The Patient Health Questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatry 2010; 32(4): 345-59.
[http://dx.doi.org/10.1016/j.genhosppsych.2010.03.006] [PMID: 20633738]
[17]
Tully PJ, Wittert G, Selkow T, Baumeister H. The real world mental health needs of heart failure patients are not reflected by the depression randomized controlled trial evidence. PLoS One 2014; 9(1): e85928
[http://dx.doi.org/10.1371/journal.pone.0085928] [PMID: 24475060]
[18]
First MB, Williams JBW, Spitzer RL, Gibbon M. Structured clinical interview for DSM-IV-TR axis I disorders, clinical trials version (SCID-I/P W/psychotic screen). New York: Biometrics Research 2007.
[19]
First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS. Structured Clinical Interview for DSM-IV Axis II Personality Disorders, (SCID-II). Washington, D.C.: American Psychiatric Press, Inc. 1997.
[21]
Tully PJ. A good time to panic? Premorbid and postmorbid panic disorder in heart failure affects cardiac and psychiatric cause admissions. Australas Psychiatry 2015; 23(2): 124-7.
[http://dx.doi.org/10.1177/1039856214568211] [PMID: 25630341]
[22]
Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990; 1(1): 43-6.
[http://dx.doi.org/10.1097/00001648-199001000-00010] [PMID: 2081237]
[23]
Chilcoat HD, Breslau N. Posttraumatic stress disorder and drug disorders: testing causal pathways. Arch Gen Psychiatry 1998; 55(10): 913-7.
[http://dx.doi.org/10.1001/archpsyc.55.10.913] [PMID: 9783562]
[24]
Sareen J. Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment. Can J Psychiatry 2014; 59(9): 460-7.
[http://dx.doi.org/10.1177/070674371405900902] [PMID: 25565692]
[25]
Šagud M, Jakšić N, Vuksan-Ćusa B, et al. Cardiovascular disease risk factors in patients with posttraumatic stress disorder (PTSD): a narrative review. Psychiatr Danub 2017; 29(4): 421-30.
[http://dx.doi.org/10.24869/psyd.2017.421] [PMID: 29197198]
[26]
Schopfer DW, Forman DE. Cardiac Rehabilitation in Older Adults. Can J Cardiol 2016; 32(9): 1088-96.
[http://dx.doi.org/10.1016/j.cjca.2016.03.003] [PMID: 27297002]
[27]
Lee JY, Brook JS, Finch SJ, Kim W, Brook DW. Single and dual diagnoses of major depressive disorder and posttraumatic stress disorder predicted by triple comorbid trajectories of tobacco, alcohol, and marijuana use among urban adults. Subst Abus 2019; 40(2): 221-8.
[http://dx.doi.org/10.1080/08897077.2019.1572047] [PMID: 30888260]
[28]
Blakey SM, Yi JY, Calhoun PS, Beckham JC, Elbogen EB. Why do trauma survivors become depressed? Testing the behavioral model of depression in a nationally representative sample. Psychiatry Res 2019; 272: 587-94.
[http://dx.doi.org/10.1016/j.psychres.2018.12.150] [PMID: 30616128]
[29]
Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S. Burden and consequences of child maltreatment in high-income countries. Lancet 2009; 373(9657): 68-81.
[http://dx.doi.org/10.1016/S0140-6736(08)61706-7] [PMID: 19056114]
[30]
Flory JD, Yehuda R. Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations. Dialogues Clin Neurosci 2015; 17(2): 141-50.
[PMID: 26246789]
[31]
Cahill MC, Bilanovic A, Kelly S, Bacon S, Grace SL. Screening for depression in cardiac rehabilitation: a review. J Cardiopulm Rehabil Prev 2015; 35(4): 225-30.
[http://dx.doi.org/10.1097/HCR.0000000000000101] [PMID: 25622216]
[32]
Lichtman JH, Bigger JT Jr, Blumenthal JA, et al. Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation 2008; 118(17): 1768-75.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.108.190769] [PMID: 18824640]
[33]
Ladwig KH, Lederbogen F, Albus C, et al. Position paper on the importance of psychosocial factors in cardiology: Update 2013. Ger Med Sci 2014; 12: Doc09.
[PMID: 24808816]
[34]
Sommaruga M, Angelino E, Della Porta P, et al. Best practice in psychological activities in cardiovascular prevention and rehabilitation: position paper. Monaldi Arch Chest Dis 2018; 88(2): 966.
[http://dx.doi.org/10.4081/monaldi.2018.966] [PMID: 29962189]
[35]
Tulloch H, Greenman PS, Tassé V. Post-traumatic stress disorder among cardiac patients: prevalence, risk factors, and considerations for assessment and treatment. Behav Sci (Basel) 2014; 5(1): 27-40.
[http://dx.doi.org/10.3390/bs5010027] [PMID: 25545708]
[36]
Ratcliff CG, Barrera TL, Petersen NJ, et al. Recognition of anxiety, depression, and PTSD in patients with COPD and CHF: Who gets missed? Gen Hosp Psychiatry 2017; 47: 61-7.
[http://dx.doi.org/10.1016/j.genhosppsych.2017.05.004] [PMID: 28807139]
[37]
Denollet J, Pedersen SS. Anger, depression, and anxiety in cardiac patients: the complexity of individual differences in psychological risk. J Am Coll Cardiol 2009; 53(11): 947-9.
[http://dx.doi.org/10.1016/j.jacc.2008.12.006] [PMID: 19281924]
[38]
von Känel R, Barth J, Princip M, et al. Early Psychological counseling for the prevention of posttraumatic stress induced by acute coronary syndrome: the mi-sprint randomized controlled trial. Psychother Psychosom 2018; 87(2): 75-84.
[http://dx.doi.org/10.1159/000486099] [PMID: 29462823]
[39]
Shemesh E, Annunziato RA, Weatherley BD, et al. A randomized controlled trial of the safety and promise of cognitive-behavioral therapy using imaginal exposure in patients with posttraumatic stress disorder resulting from cardiovascular illness. J Clin Psychiatry 2011; 72(2): 168-74.
[http://dx.doi.org/10.4088/JCP.09m05116blu] [PMID: 20441725]
[40]
Shemesh E, Koren-Michowitz M, Yehuda R, et al. Symptoms of posttraumatic stress disorder in patients who have had a myocardial infarction. Psychosomatics 2006; 47(3): 231-9.
[http://dx.doi.org/10.1176/appi.psy.47.3.231] [PMID: 16684940]
[41]
Ford J, Rosman L, Wuensch K, Irvine J, Sears SF. Cognitive-behavioral treatment of posttraumatic stress in patients with implantable cardioverter defibrillators: results from a randomized controlled trial. J Trauma Stress 2016; 29(4): 388-92.
[http://dx.doi.org/10.1002/jts.22111] [PMID: 27415850]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy