Effect of Aging on Metabolic Pathways in Endothelial Progenitor Cells

Francesca      Felice; Maria      Chiara Barsotti; Pavel      Poredos; Alberto      Balbarini; Rossella      Di Stefano

doi:10.2174/1381612811319130003

Abstract

Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are needed. The relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPC) mediate repair mechanisms for endothelial regeneration and maintenance, but they are subject to ageassociated changes affecting negatively their number and/or function.

Aim of this review is to examine the impact of age on EPC-mediated vascular repair, with a focus on the metabolic pathways involved and on the therapeutic targets with potential for attenuating this effect.

Keywords: Aging, senescence, vascular disease, endothelial progenitor cells, metabolic pathways, repair mechanisms, vascular repair, endothelial regeneration, pathologies, therapeutic targets