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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

A Study for Therapeutic Treatment against Parkinson’s Disease via Chou’s 5-steps Rule

Author(s): Jianqiang Lan, Zhongqiang Liu, Chenghong Liao, David J. Merkler, Qian Han* and Jianyong Li*

Volume 19, Issue 25, 2019

Page: [2318 - 2333] Pages: 16

DOI: 10.2174/1568026619666191019111528

Price: $65

Abstract

The enzyme L-DOPA decarboxylase (DDC), also called aromatic-L-amino-acid decarboxylase, catalyzes the biosynthesis of dopamine, serotonin, and trace amines. Its deficiency or perturbations in expression result in severe motor dysfunction or a range of neurodegenerative and psychiatric disorders. A DDC substrate, L-DOPA, combined with an inhibitor of the enzyme is still the most effective treatment for symptoms of Parkinson's disease. In this review, we provide an update regarding the structures, functions, and inhibitors of DDC, particularly with regards to the treatment of Parkinson's disease. This information will provide insight into the pharmacological treatment of Parkinson's disease.

Keywords: L-DOPA decarboxylase, Aromatic-L-amino-acid decarboxylase, Inhibitor, Parkinson’s disease, Enzyme, Biosynthesis.

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