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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

Synthetic Approach for Substituted 3-Amino-1,2,4-Triazines and their Chemical Reactivity and Biological Properties

Author(s): Reda M. Abdel-Rahman, Mohammed A. Assiri, Ahmed M. Fouda and Tarik E. Ali*

Volume 17, Issue 5, 2020

Page: [605 - 624] Pages: 20

DOI: 10.2174/1570193X16666190724105040

Price: $65

Abstract

3-Amino-1,2,4-triazines are considered versatile compounds for its significance as building blocks in synthetic and pharmaceutical chemistry. The synthesis, chemical reactivity, and applications of substituted 1,2,4-triazines bearing an amino group were described in this review. The presence of the amino group at position 3 exhibited unique reactivities towards carbonitrile, carbonyl and isothiocyanate reagents. The reactions were divided into several categories, depending on the other substituents on the 1,2,4-triazine ring. In this review, relevant and appropriate applications of the synthesized, isolated, and condensed heterocycles derivatives were reported.

Keywords: 1, 2, 4-Triazines, pharmacological, reactivity, pharmaceutical chemistry, isothiocyanate reagents, synthesis.

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