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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Review of Progress in Predicting Protein Methylation Sites

Author(s): Chunyan Ao, Shunshan Jin, Yuan Lin * and Quan Zou*

Volume 23, Issue 15, 2019

Page: [1663 - 1670] Pages: 8

DOI: 10.2174/1385272823666190723141347

Price: $65

Abstract

Protein methylation is an important and reversible post-translational modification that regulates many biological processes in cells. It occurs mainly on lysine and arginine residues and involves many important biological processes, including transcriptional activity, signal transduction, and the regulation of gene expression. Protein methylation and its regulatory enzymes are related to a variety of human diseases, so improved identification of methylation sites is useful for designing drugs for a variety of related diseases. In this review, we systematically summarize and analyze the tools used for the prediction of protein methylation sites on arginine and lysine residues over the last decade.

Keywords: Protein methylation, Support Vector Machine (SVM), methyllysine, methylarginine, arginine residue, lysine residue, cysteine residues.

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