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Medicinal Chemistry

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ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

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Review Article

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Author(s): Xiao-hua Cai*, Hong-yan Zhang and Bing Xie*

Volume 16, Issue 4, 2020

Page: [431 - 453] Pages: 23

DOI: 10.2174/1573406415666190507121744

Price: $65

Abstract

Matrine-family alkaloids as tetracycloquinolizindine analogues from Traditional Chinese Medicine Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L possess various pharmacological activities and have aroused great interests over the past decades. Especially, a lot of matrine derivatives have been designed and synthesized and their biological activities investigated, and encouraging results have continuously been achieved in recent several years. These studies are helpful to develop more potent candidates or therapeutic agents and disclose their molecular targets and mechanisms. This paper reviews recent advances in the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification.

Keywords: Alkaloid, matrine-family alkaloid, sophoridine, Sophora species, matrine, bioactive modification.

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