Abstract
Functionalized gem-bisphosphonic acid derivatives being pyrophosphate isosteres are of great synthetic and biological interest since they are currently the most important class of drugs developed for the treatment of diseases associated with the disorder of calcium metabolism, including osteoporosis, Paget’s disease, and hypercalcemia. In this article, we will try to give an in-depth overview of the methods for obtaining α- heteroatom-substituted methylenebisphosphonates and acquaint the reader with the synthetic strategies that are used to develop biologically important compounds of this type.
Keywords: Arbuzov reaction, bioactive compounds, bisphosphonates, bisphosphonic acids, bisphosphonate complexes, cycloaddition reactions, diazobisphosphonates, enzyme inhibitors, insertion reactions, medicinal chemistry, modified polyphosphates, Michael addition, Michaelis-Becker reaction, multicomponent reactions, phosphate mimics, phosphonates, phosphonate carbanions, phosphonic acid group, phosphonylating reactions, pyrophosphate analogues, synthetic methods, trisphosphonates.
Graphical Abstract
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Call for Papers in Thematic Issues
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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