Triple Antithrombotic Therapy vs. Double Antithrombotic Therapy: One Scenario, 8 Questions, Many Conclusions

Title:Triple Antithrombotic Therapy vs. Double Antithrombotic Therapy: One Scenario, 8 Questions, Many Conclusions

Volume: 15 Issue: 3

Author(s): Elio Aloia*, Paolo Orselli and Carlotta Sciaccaluga

Affiliation:

• Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena,Italy

Keywords: Triple antithrombotic therapy, dual antithrombotic therapy, atrial fibrillation, Percutaneous Coronary Intervention (PCI), NOAC, OAC.

Abstract: In patients with atrial fibrillation undergoing percutaneous coronary intervention with the placement of stents, a triple antithrombotic therapy is empirically established, which consists of a combination of dual antithrombotic therapy (aspirin plus a P2Y12 inhibitor) and an oral anticoagulant agent. This choice is guided by the desirable result of reducing cerebrovascular and coronary ischemic events. However, there is an unwelcome outcome: an increased incidence of bleeding. On this matter, in 2018, a North American Perspective Update was published, about a year later it was followed by the publication of the European focus update on the dual antiplatelet therapy. After analysing the main differences between these two consensus documents, this review aims at examining the major studies on which they are based on, as a starting point to define the foundation of new trials that can help shed light on this prominent topic.

Cite this article as:

Aloia Elio *, Orselli Paolo and Sciaccaluga Carlotta , Triple Antithrombotic Therapy vs. Double Antithrombotic Therapy: One Scenario, 8 Questions, Many Conclusions, Current Cardiology Reviews 2019; 15 (3) . https://dx.doi.org/10.2174/1573403X15666190111095438