Abstract
Background: Esophageal cancer (EC) is a common digestive system tumor, characterized by high invasion, apparent lethality, and poor prognosis. Direct diffusion is the major metastatic mechanism of early EC, whereas advanced EC is spread mainly by lymphatic metastasis, but also can be transferred to the liver, lungs, bones, and so on, by hematogenous metastasis. The incidence of bone metastasis in esophageal cancer is low, and maxillary metastasis of EC is more rare.
Objective: To explore the differential diagnosis in ECMM, the rare metastasis of EC, and the possible mechanisms and predictors of bone metastasis.
Methods: The clinical materials of a male patient with maxillary metastasis of esophageal cancer (ECMM) were analyzed. Then, the possible mechanism of the ECMM was discussed.
Conclusion: ECMM may belong to the hematogenous metastasis. The early detection of rare sites of metastasis of EC should be prioritized in tumor marker detection, imaging, pathology, and other diagnostic techniques.
Keywords: Esophageal cancer, bone metastasis, maxilla, metastasis mechanism, rare case, review.
[1]
Lagergren, J. Oesophageal cancer in 2014: Advances in curatively intended treatment. Nat. Rev. Gastroenterol. Hepatol., 2015, 12(2), 74-75.
[2]
Alsop, B.R.; Sharma, P. Esophageal Cancer. Gastroenterol. Clin. North Am., 2016, 45(3), 399-412.
[3]
Nakajima, Y.; Ohta, S.; Okada, T.; Miyawaki, Y.; Hoshino, A.; Suzuki, T.; Kawada, K.; Nishikage, T.; Nagai, K.; Ae, K.; Kawachi, H.; Kawano, T. Osteoplastic bone metastasis in esophageal squamous cell cancer: report of a case. Surg. Today, 2012, 42(4), 376-381.
[4]
Quint, L.E.; Hepburn, L.M.; Francis, I.R.; Whyte, R.I.; Orringer, M.B. Incidence and distribution of distant metastases from newly diagnosed esophageal carcinoma. Cancer, 1995, 76(7), 1120-1125.
[5]
Umebayashi, Y. Metastasis of esophageal carcinoma manifesting as whitlow-like lesions. J. Dermatol., 1998, 25(4), 256-259.
[6]
Sharma, S.; Anamika, S.; Ramachandra, S.S. Peripheral ossifying fibroma: A clincal report. Compend. Contin. Educ. Dent., 2011, 32(5), E86-E90.
[7]
Buduneli, E.; Buduneli, N.; Unal, T. Long-term follow-up of peripheral ossifying fibroma: Report of three cases. Periodontal Clin. Investig., 2001, 23(1), 11-14.
[8]
Malik, U.U.; Zarina, S.; Pennington, S.R. Oral squamous cell carcinoma: Key clinical questions, biomarker discovery, and the role of proteomics. Arch. Oral Biol., 2016, 63, 53-65.
[9]
Stiekema, J.; Vermeulen, D.; Vegt, E.; Voncken, F.E.; Aleman, B.M.; Sanders, J.; Boot, H.; van Sandick, J.W. Detecting interval metastases and response assessment using 18F-FDG PET/CT after neoadjuvant chemoradiotherapy for esophageal cancer. Clin. Nucl. Med., 2014, 39(10), 862-867.
[10]
Malik, V.; Harmon, M.; Johnston, C.; Fagan, A.J.; Claxton, Z.; Ravi, N.; O’Toole, D.; Muldoon, C.; Keogan, M.; Reynolds, J.V.; Meaney, J.F. Whole body MRI in the staging of esophageal cancer--A prospective comparison with whole body 18F-FDG PET-CT. Dig. Surg., 2015, 32(5), 397-408.
[11]
Onodera, Y.; Nakano, T.; Heishi, T.; Sakurai, T.; Taniyama, Y.; Sato, C.; Ohuchi, N.; Kamei, T. Bilateral approach for thoracoscopic esophagectomy with lymph node dissection in the dorsal area of the thoracic aorta in patients with esophageal cancer: A report of two cases. Int. J. Surg. Case Rep., 2017, 31, 154-158.
[12]
Kobayashi, K.; Suto, Y.; Akashi, O.; Sakata, Y.; Hayama, Y.; Kon, J.; Chino, O. Pericardial fenestration in a patient with myocardial metastasis and cardiac tamponade after surgery for esophageal cancer; Report of a case. Kyobu Geka, 2016, 69(10), 869-872.
[13]
Oshiro, H.; Osaka, Y.; Tachibana, S.; Aoki, T.; Tsuchiya, T.; Nagao, T. Retrograde lymphatic spread of esophageal cancer: A case report. Medicine (Baltimore), 2015, 94(27), e1139.
[14]
Vidović, V.; Nikolić, I.; Vukojević, J.; Samardžija, G.; Kukić, B.; Bogdanović, B.; Petrović, N. Unusual metastasis of esophageal cancer. Vojnosanit. Pregl., 2014, 71(10), 975-977.
[15]
Kobayashi, Y.; Nozawa, M.; Kikuchi, T.; Nishimoto, M.; Shimizu, N.; Yamamoto, Y.; Minami, T.; Hayashi, T.; Tsuji, H.; Yoshimura, K.; Ishii, T.; Uemura, H. Penile metastasis from esophageal cancer: a case report. Hinyokika Kiyo, 2013, 59(5), 315-318.
[16]
Sanyal, S.; Kaman, L.; Sinha, S.K. Splenic metastasis from esophageal cancer: Report of a case. Surg. Today, 2005, 35(11), 988-990.
[17]
Tatai, T.; Sasaki, S.; Sekiguchi, N.; Koizumi, T. Iris metastasis of esophageal cancer. Ann. Thorac. Surg., 2005, 79(5), 1782-1784.
[18]
Nakamura, Y.; Nakano, K.; Gomi, A.; Nakatani, H.; Saegusa, N.; Matsuya, S.; Imai, T. A metastatic ball tumor in the right atrium originating from esophageal cancer: Report of a case. Surg. Today, 2005, 35(2), 145-148.
[19]
Cruz Guerra, N.A.; Allona Almagro, A.; Cuesta Roca, C.; Sanz Migueláñez, J.L.; García González, R.; Escudero Barrilero, A. Solitary renal metastasis of primary esophageal cancer. Actas Urol. Esp., 2000, 24(8), 679-681.
[20]
Shiraishi, M.; Itoh, T.; Furuyama, K.; Yamasaki, S.; Shimada, Y.; Hosotani, R.; Nakashima, Y.; Imamura, M. Case of metastatic breast cancer from esophageal cancer. Dis. Esophagus, 2001, 14(2), 162-165.
[21]
Ledderose, G.J.; Englhard, A.S. Isolated nasal tip metastasis from esophageal squamous cell carcinoma: Case report and literature review. Case Rep. Otolaryngol., 2015, 2015, 246094.
[22]
Pokharel, S.; Kabbach, G.; Richter, S.J.; Chiu, L. Metastatic esophageal cancer presenting as an orbital mass. ACG Case Rep. J., 2016, 3(4), e154.
[23]
Na, M.K.; Kim, C.H.; Kim, J.M.; Cheong, J.W.; Ryu, J.I.; Kim, H.W. Multiple meningocerebral metastasis and extensive skull metastasis from squamous cell carcinoma of esophagus: A case report and review of literature. Brain Tumor Res. Treat., 2016, 4(2), 142-144.
[24]
Levack, B.; Scott, G.; Flanagan, J.P. Metastatic carcinoma presenting as a pulp space infection. Hand, 1983, 15(3), 341-342.
[25]
Sánchez-Jiménez, J.; Acebal-Blanco, F.; Arévalo-Arévalo, R.E.; Molina-Martínez, M. Metastatic tumours in upper maxillary bone of esophageal adenocarcinoma. A case report. Med. Oral Patol. Oral Cir. Bucal, 2005, 10(3), 252-257.
[26]
Lawes, K.P.; Danford, M.; Di Palma, S. Delayed metastasis to the mandible of esophageal adenocarcinoma. Head Neck Pathol., 2013, 7(4), 416-420.
[27]
Baar, J.; Burkes, R.L.; Bell, R.; Blackstein, M.E.; Fernandes, B.; Langer, F. Primary non-Hodgkin’s lymphoma of bone. A clinicopathologic study. Cancer, 1994, 73(4), 1194-1199.
[28]
Nguyen, D.X.; Massague, J. Genetic determinants of cancer metastasis. Nat. Rev. Genet., 2007, 8(5), 341-352.
[29]
Paget, S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev., 1989, 8(2), 98-101.
[30]
Bellanger, A.; Donini, C.F.; Vendrell, J.A.; Lavaud, J.; Machuca-Gayet, I.; Ruel, M.; Vollaire, J.; Grisard, E.; Győrffy, B.; Bièche, I.; Peyruchaud, O.; Coll, J.L.; Treilleux, I.; Maguer-Satta, V.; Josserand, V.; Cohen, P.A. The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone. J. Pathol., 2017, 242(1), 73-89.
[31]
Day, K.C.; Lorenzatti Hiles, G.; Kozminsky, M.; Dawsey, S.J.; Paul, A.; Broses, L.J.; Shah, R.; Kunja, L.P.; Hall, C.; Palanisamy, N.; Daignault-Newton, S.; El-Sawy, L.; Wilson, S.J.; Chou, A.; Ignatoski, K.W.; Keller, E.; Thomas, D.; Nagrath, S.; Morgan, T.; Day, M.L. HER2 and EGFR overexpression support metastatic progression of prostate cancer to bone. Cancer Res., 2017, 77(1), 74-85.
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