Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting

Title:Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting

Volume: 24 Issue: 28

Author(s): Xia Li*, Fenglin Zhang, Hualan Zhou, Youdong Hu, Xiang Fang, Dianxuan Guo and Ying Chen

Affiliation:

• Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an,China

Keywords: Coronary heart disease, coronary stenting, coronary artery, in-stent reocclusion, atherosclerosis, oxidative stress.

Abstract: Background: Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80～90 years) after coronary stenting.

Methods: We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein（ACR）, and paraoxonase-1 （PON-1）in advanced age patients with in-stent restenosis and reocclusion after coronary stenting.

Results: Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001).

Conclusion: The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.

Cite this article as:

Li Xia *, Zhang Fenglin , Zhou Hualan , Hu Youdong , Fang Xiang , Guo Dianxuan and Chen Ying , Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting, Current Pharmaceutical Design 2018; 24 (28) . https://dx.doi.org/10.2174/1381612824666180830141918