The Possible Impact of Hyperuricemia on Serum Soluble Receptor for Advanced Glycation end Products (sRAGE) Levels in Teenagers: A Case Control Study

Title:The Possible Impact of Hyperuricemia on Serum Soluble Receptor for Advanced Glycation end Products (sRAGE) Levels in Teenagers: A Case Control Study

Volume: 24 Issue: 27

Author(s): Marta Lemiesz, Edyta Tenderenda-Banasiuk, Dorota Sosnowska, Agnieszka Rybi-Szumińska, Justyna Storonowicz, Tomasz Lemiesz*Anna Wasilewska

Affiliation:

• Department of General Surgery and Urology, Hospital of the Ministry of Interior and Administration in Bialystok, Bialystok,Poland

Keywords: Adolescents, AGEs, Children, Hypertension, Hyperuricemia, sRAGE.

Abstract: Background: Dietary advanced glycation end products (AGEs) and their interactions with the soluble receptors for AGEs (RAGE) play a crucial role in the pathogenesis of cardiovascular diseases.

Objective: This study was set out to assess, whether there was any association between serum sRAGE level and serum uric acid level in children with hyperuricemia.

Methods: This case-control study involved 53 patients (12 girls, 41 boys) with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) aged (median [IQR]) (15.5 [13.5-15.5] years). Thirty-six healthy individuals with normal serum uric acid level were selected as a reference group. Additionally, the study group with hyperuricemia was divided into two groups: HU-HT (hypertensive n=25) and HU-NT (normotensive n=28) teenagers. The serum concentration of human sRAGE was measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.

Results: We found statistically significant differences in serum sRAGE levels between normotensive subjects with hyperuricemia (median [IQR]) (169.8 [148.3-231.1] pg/ml) and reference group (median [IQR]) (129 [107.4-175.3] pg/ml), p<0.01. Univariate analysis of the data revealed a positive correlation between serum sRAGE and serum uric acid in the study group (r=0.306, p<0.05).

Conclusion: Our data showed that serum soluble receptors for AGEs are increased in teenagers with hyperuricemia. In contrast, neither hypertension nor increased BMI had a significant influence on serum sRAGE concentration. Further studies are needed to discover the possible mechanism on the influence of uric acid on sRAGE levels and to assess its possible clinical significance.

Cite this article as:

Lemiesz Marta, Tenderenda-Banasiuk Edyta, Sosnowska Dorota, Rybi-Szumińska Agnieszka, Storonowicz Justyna, Lemiesz Tomasz*, Wasilewska Anna, The Possible Impact of Hyperuricemia on Serum Soluble Receptor for Advanced Glycation end Products (sRAGE) Levels in Teenagers: A Case Control Study, Current Pharmaceutical Design 2018; 24 (27) . https://dx.doi.org/10.2174/1381612824666180813114127