Inflammatory Cells and Proteases in Abdominal Aortic Aneurysm and its Complications

Title:Inflammatory Cells and Proteases in Abdominal Aortic Aneurysm and its Complications

Volume: 19 Issue: 11

Author(s): Haiying Jiang, Takeshi Sasaki, Enze Jin, Masafumi Kuzuya and Xian Wu Cheng*

Affiliation:

• Department of Cardiology and Heart Center/Hypertension, Yanbian University Hospital, Yanji 133000, Jilin Prov.,China

Keywords: Abdominal aortic aneurysm, inflammatory cells, proteases, extracellular matrix, macrophages, atherosclerosis.

Abstract: Abdominal aortic aneurysm (AAA), a common disease among elderly individuals, involves the progressive dilatation of the abdominal aorta as a consequence of degeneration. The mechanisms of AAA formation, development and rupture are largely unknown. Surgical repair is the only available method of treatment since the lack of knowledge regarding the pathogenesis of AAA has hindered the development of suitable medical treatments, particularly the development of drugs. In this review, we describe the inflammatory cells and proteases that may be involved in the formation and development of AAA. This knowledge can contribute to the development of new drugs for AAA.

Cite this article as:

Jiang Haiying , Sasaki Takeshi , Jin Enze , Kuzuya Masafumi and Cheng Wu Xian*, Inflammatory Cells and Proteases in Abdominal Aortic Aneurysm and its Complications, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666180531103458