The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions

Title:The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions

Volume: 18 Issue: 7

Author(s): Robert A. Hillman, Jonathan W. Nadraws and Michael A. Bertucci*

Affiliation:

• Department of Chemistry, Moravian College, Bethlehem, PA 18018,United States

Keywords: Stapled peptides, protein-protein interactions, peptide therapeutics, hydrocarbon, infectious disease, cancer.

Abstract: Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine disorders and cardiovascular disease. Stapled peptides are an emerging intervention for these PPIs due to their improved structural rigidity and pharmacokinetic properties relative to unstapled peptides. This review details the most recent advances in the field of stapled peptide therapeutics, including the increasing variety of PPIs being targeted and types of peptide staples being employed.

Cite this article as:

Hillman A. Robert , Nadraws W. Jonathan and Bertucci A. Michael *, The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions, Current Topics in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1568026618666180518095255