Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an In vivo and In vitro Study

Title:Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an In vivo and In vitro Study

Volume: 16 Issue: 1

Author(s): Nima Naderi, Seyed Mostafa Ghasemi Najarkolaee, Mona Modanlookordi, Mohammad Shokrzadeh and Hamid Irannejad*

Affiliation:

• Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari,Iran

Keywords: Genoprotection, 1, 2, 4-triazine, anti-inflammatory, endosulfan, neuroprotective, neurotic cell lines.

Abstract: Background: Recently, we reported synthesis and neuroprotective activity of some new 1,2,4-triazine derivatives against H2O2 and β-amyloid toxicity in two neurotic cell lines, SHSY5Y and PC12.

Methods: The promising results obtained prompted us to further study on these potent neuroprotective agents. In the current study, in vivo anti-inflammatory effect and also genoprotective activity of these compounds in endosulfan-mediated toxicity were investigated. Compounds RT and SMO exhibited high anti-inflammatory effect at 3 and 4 hours after injection in 20 mg/kg, and were even more effective than Indomethacin (20 mg/kg).

Results: Interestingly, compound SMO in 200 µM was the best compound in reducing micronuclei significantly (P value <0.0001) in lymphocytes treated with endosulfan compared to control group.

Conclusion: Herein, we report SMO as a genoprotective agent and a new drug candidate for endosulfan mediated toxicity.

Cite this article as:

Naderi Nima, Najarkolaee Mostafa Ghasemi Seyed, Modanlookordi Mona, Shokrzadeh Mohammad and Irannejad Hamid*, Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an In vivo and In vitro Study, Letters in Drug Design & Discovery 2019; 16 (1) . https://dx.doi.org/10.2174/1570180815666180420095446