Abstract
The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
Current Molecular Medicine
Title:Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
Volume: 17 Issue: 10
Author(s): N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*
Affiliation:
- Department of Chemical Engineering, American University of Sharjah, Sharjah,United Arab Emirates
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
Abstract: The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
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Cite this article as:
Salkho N.M., Turki R.Z., Guessoum O., Martins A.M., Vitor R.F. and Husseini G.A.*, Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment, Current Molecular Medicine 2017; 17 (10) . https://dx.doi.org/10.2174/1566524018666180416100142
DOI https://dx.doi.org/10.2174/1566524018666180416100142 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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