Roles of TRAF6 in Central Nervous System

Title:Roles of TRAF6 in Central Nervous System

Volume: 16 Issue: 9

Author(s): Yang Dou, Xiaodi Tian, Jian Zhang, Zhong Wang and Gang Chen*

Affiliation:

• Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006,China

Keywords: TRAF6, E3 ubiquitin ligase, ubiquitination, inflammation, ROS, central nervous system diseases.

Abstract: Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and acquired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special facture and biological function. TRAF6 has two special domains: C-terminal domain and N-terminal domain, which could integrate with multiple kinases and regulate signaling pathway function as an E3 ubiquitin ligase. Studies have increasingly found that TRAF6 is closely related to central nervous system diseases, such as stroke, Traumatic brain injury, neurodegenerative diseases and neuropathic pain. Further research on the pathophysiological mechanism may be expected to become the new targets for the treatment of central nervous system diseases.

Cite this article as:

Dou Yang , Tian Xiaodi , Zhang Jian, Wang Zhong and Chen Gang *, Roles of TRAF6 in Central Nervous System, Current Neuropharmacology 2018; 16 (9) . https://dx.doi.org/10.2174/1570159X16666180412094655