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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Synthesis of Hitherto Unknown 4,4-Bis(methylthio)but-3-en-2-one-1,1,1,3- d4 and Its Application as 1,3-Dielectrophilic Building Block for the Synthesis of Deuterated Heterocycles and Aromatics

Author(s): T.P. Charanraj, P. Ramachandra, N. Ramesh and H. Junjappa*

Volume 15, Issue 5, 2018

Page: [412 - 417] Pages: 6

DOI: 10.2174/1570178615666171205095718

Price: $65

Abstract

Acetone-d6 has been transformed for the first time to 4,4-bis(methylthio)but-3-en-2-one- 1,1,1,3-d4. This tetradeutero-α-oxoketenedithioacetal is shown to be an excellent 1,3-dielectrophilic building block for the synthesis of 5- and 6-membered deuterated heterocycles and aromatics.

Keywords: Acetone-d6, α-oxoketenedithioacetal, 1, 3-dielectrophilic building block, deuterated heterocycles, aromatics, aromatic compounds.

Graphical Abstract


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