Abstract
Background: Quinoxaline is an important nucleus used in the development of novel potentially bioactive structures. Hence, the development of new methodologies that provide access to this scaffold in shorter times and increased yields is of interest. In this work, we review many interesting microwave-assisted methodologies for the synthesis of quinoxalines reported from 2007 to 2015.
Methods: The most prominent methods for the synthesis of quinoxalines under microwave irradiation published in articles from 2007-2015 are reviewed.
Conclusion: Microwave irradiation proved to be a useful tool, providing many advantages on the synthesis of this class, such as shorter reaction times, higher yields and better selectivity, when compared to classical procedures.
Keywords: Catalysis, drugs, green chemistry, microwave, quinoxaline, synthesis.
Graphical Abstract
Current Microwave Chemistry
Title:Microwave-Assisted Synthesis of Quinoxalines - A Review
Volume: 4 Issue: 4
Author(s): Cristiane Franca da Costa, Marcus Vinicius Nora de Souza*, Claudia Regina Brandao Gomes and Victor Facchinetti
Affiliation:
- Departamento de Sintese de Farmacos, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro,Brazil
Keywords: Catalysis, drugs, green chemistry, microwave, quinoxaline, synthesis.
Abstract: Background: Quinoxaline is an important nucleus used in the development of novel potentially bioactive structures. Hence, the development of new methodologies that provide access to this scaffold in shorter times and increased yields is of interest. In this work, we review many interesting microwave-assisted methodologies for the synthesis of quinoxalines reported from 2007 to 2015.
Methods: The most prominent methods for the synthesis of quinoxalines under microwave irradiation published in articles from 2007-2015 are reviewed.
Conclusion: Microwave irradiation proved to be a useful tool, providing many advantages on the synthesis of this class, such as shorter reaction times, higher yields and better selectivity, when compared to classical procedures.
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Cite this article as:
da Costa Franca Cristiane , Nora de Souza Vinicius Marcus *, Brandao Gomes Regina Claudia and Facchinetti Victor , Microwave-Assisted Synthesis of Quinoxalines - A Review, Current Microwave Chemistry 2017; 4 (4) . https://dx.doi.org/10.2174/2213335604666171010153416
DOI https://dx.doi.org/10.2174/2213335604666171010153416 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
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