Abstract
The following review analyzes the most effective activation protocols for the generation of transient electrophilic quinone methides, merged into the recent strategies to achieve recognition and alkylation of nucleic acids. The covalent targeting has to be specific for selected oligonucleotide sequences (sequence-specificity) or for those oligonucleotides capable to fold into supramolecular structures, such as G-quadruplexes (structure-specificity). The reversibility of the DNA alkylation process by QM is reviewed underlining the opportunities (in term of selectivity and delivery) and drawbacks (in term of product characterization of the covalent damage) in the DNA targeting.
Keywords: Alkylation, cross-linking, nucleic acids, quinone methides, reversibility, sequence-specificity, structure-specificity.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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