Abstract
Baculoviruses are safe and high-capacity vectors for gene delivery which have matured from the initial successful experiments performed in liver cells into convenient tools to transduce almost any cell from any origin in vitro and ex vivo. This is a result of 15 years of intensive vector development as well as studies performed in vertebrate cells to reveal important factors affecting the transduction efficacy. Now, at the stage when the first evidence of meaningful use of baculoviruses for therapeutic applications has been reported, there is no doubt that the technology will meet the expectations as highly useful platform for many applications of gene delivery. This review summarizes the pre-clinical in vivo work carried out with baculoviruses and discusses remaining challenges which still need to be solved.
Keywords: Baculoviruses, BacMam, gene therapy, transduction, imaging
Current Gene Therapy
Title: In Vivo Application and Tracking of Baculovirus
Volume: 10 Issue: 3
Author(s): Kari J. Airenne, Kaisa-Emilia Makkonen, Anssi J. Mahonen and Seppo Yla-Herttuala
Affiliation:
Keywords: Baculoviruses, BacMam, gene therapy, transduction, imaging
Abstract: Baculoviruses are safe and high-capacity vectors for gene delivery which have matured from the initial successful experiments performed in liver cells into convenient tools to transduce almost any cell from any origin in vitro and ex vivo. This is a result of 15 years of intensive vector development as well as studies performed in vertebrate cells to reveal important factors affecting the transduction efficacy. Now, at the stage when the first evidence of meaningful use of baculoviruses for therapeutic applications has been reported, there is no doubt that the technology will meet the expectations as highly useful platform for many applications of gene delivery. This review summarizes the pre-clinical in vivo work carried out with baculoviruses and discusses remaining challenges which still need to be solved.
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Cite this article as:
J. Airenne Kari, Makkonen Kaisa-Emilia, J. Mahonen Anssi and Yla-Herttuala Seppo, In Vivo Application and Tracking of Baculovirus, Current Gene Therapy 2010; 10 (3) . https://dx.doi.org/10.2174/156652310791321206
DOI https://dx.doi.org/10.2174/156652310791321206 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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