The Measurement and Mathematical Analysis of 5-Fu Release from Magnetic Polymeric Nanocapsules, following the Application of Ultrasound

Title:The Measurement and Mathematical Analysis of 5-Fu Release from Magnetic Polymeric Nanocapsules, following the Application of Ultrasound

Volume: 18 Issue: 3

Author(s): Ziaeddin Abed, Samideh Khoei, Behafarid Ghalandari, Jaber Beik, Ali Shakeri-Zadeh, Habib Ghaznavi*Mohammad-Bagher Shiran*

Affiliation:

• Department of Pharmacology, Zahedan University of Medical Sciences (ZaUMS), Zahedan,Iran

• Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran,Iran

Keywords: Cancer, chemotherapy, ultrasound, drug release, magnetic polymeric nanoparticles, mathematical analysis.

Abstract: Objective: To study the effects of ultrasound irradiation on the release profile of 5-fluorouracil (5-Fu) loaded magnetic poly lactic co-glycolic acid (PLGA) nanocapsules. Also, the controlled drug-release behaviour of the nanocapsules was mathematically investigated.

Methods: The nanocapsules were synthesized, dispersed in phosphate buffered saline (PBS), transferred to a dialysis bag, and finally, irradiated by various ultrasound parameters (1 or 3MHz; 0.3-1W/cm2; 5-10 minutes). The release profile of the irradiated nanocapsules was recorded for 14 days. To find the in vitro drug release mechanism in the absence and presence of various intensities of ultrasound, the obtained data were fitted in various kinetic models for drug release.

Results: The results demonstrated that the ultrasound speeded up the rate of drug release from the nanocapsules. The mathematical analysis illustrated that when the ultrasound intensity is increased, the probability of controlled release behaviour of the nanocapsules is raised. We found that drug release from the irradiated nanocapsules follows an erosion-controlled mechanism with the decrease in the velocity of diffusion.

Conclusion: In conclusion, to attain a controlled drug-delivery strategy in the area of cancer therapy, the drug release profile of the nano-carriers may be well-controlled by ultrasound.

Cite this article as:

Abed Ziaeddin , Khoei Samideh , Ghalandari Behafarid , Beik Jaber , Shakeri-Zadeh Ali , Ghaznavi Habib *, Shiran Mohammad-Bagher*, The Measurement and Mathematical Analysis of 5-Fu Release from Magnetic Polymeric Nanocapsules, following the Application of Ultrasound, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (3) . https://dx.doi.org/10.2174/1871520617666170921124951