Novel Findings of Anti-cancer Property of Propofol

Title:Novel Findings of Anti-cancer Property of Propofol

Volume: 18 Issue: 2

Author(s): Jiaqiang Wang, Chien-shan Cheng, Yan Lu, Xiaowei Ding, Minmin Zhu, Changhong Miao*Jiawei Chen*

Affiliation:

• Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032,China

• Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032,China

Keywords: Propofol, anesthetic, general anesthesia, neoplasms, anti-cancer, malignance-modulating.

Abstract: Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.

Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.

Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.

Cite this article as:

Wang Jiaqiang , Cheng Chien-shan , Lu Yan , Ding Xiaowei, Zhu Minmin , Miao Changhong *, Chen Jiawei *, Novel Findings of Anti-cancer Property of Propofol, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1871520617666170912120327