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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells

Author(s): Maria Ines Herrera*, Sofia Mucci*, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani*

Volume 23, Issue 26, 2017

Page: [3899 - 3906] Pages: 8

DOI: 10.2174/1381612823666170727145422

Price: $65

Abstract

Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.

Keywords: brain injury, hypoxia-ischemia, pharmacological treatments, glial cells, neuroprotection

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