Abstract
Tetracyclines possess anti-inflammatory characteristics which are largely independent of their antibacterial activity. A variety of in vitro biologic effects have been reported for tetracyclines in both immune and non-immune cells. The in vivo therapeutic efficacy of tetracyclines in diseases such as rheumatoid arthritis, multiple sclerosis, and stroke has also been demonstrated in both animal models and clinical studies. This review describes the experimental evidence which demonstrates the various non-antibacterial anti-inflammatory activities of tetracyclines and discusses possible mechanisms of action of these drugs.
Keywords: Tetracycline, inflammation, autoimmunity, therapy, gastrointestinal symptoms, photosensitivity, tissue discoloration, allergic reaction, antibiotics, metalloproteases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease
Volume: 10 Issue: 2
Author(s): P. J. Higgins, M. Draper and M. Nelson
Affiliation:
Keywords: Tetracycline, inflammation, autoimmunity, therapy, gastrointestinal symptoms, photosensitivity, tissue discoloration, allergic reaction, antibiotics, metalloproteases
Abstract: Tetracyclines possess anti-inflammatory characteristics which are largely independent of their antibacterial activity. A variety of in vitro biologic effects have been reported for tetracyclines in both immune and non-immune cells. The in vivo therapeutic efficacy of tetracyclines in diseases such as rheumatoid arthritis, multiple sclerosis, and stroke has also been demonstrated in both animal models and clinical studies. This review describes the experimental evidence which demonstrates the various non-antibacterial anti-inflammatory activities of tetracyclines and discusses possible mechanisms of action of these drugs.
Export Options
About this article
Cite this article as:
J. Higgins P., Draper M. and Nelson M., Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (2) . https://dx.doi.org/10.2174/1871523011109020132
DOI https://dx.doi.org/10.2174/1871523011109020132 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Common Genetic Conditions of Ischemic Stroke to Keep in Mind
Current Molecular Medicine Molecular Targets and Abdominal Aortic Aneurysms
Recent Patents on Cardiovascular Drug Discovery Spontaneous Isolated Dissection of Iliac Artery: Unique Vascular Event Resulting from Various Etiologies
Vascular Disease Prevention (Discontinued) Physical and Mechanical Therapies for Lower Limb Problems in Children with Joint Hypermobility Syndrome: A Systematic Review Protocol
Applied Clinical Research, Clinical Trials and Regulatory Affairs Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese
Endocrine, Metabolic & Immune Disorders - Drug Targets Management and Outcomes of Aortic Dissection in Pregnancy with Marfan Syndrome: A Systematic Review
Current Vascular Pharmacology Transforming Growth Factor-β Signaling in Motor Neuron Diseases
Current Molecular Medicine Novel Biomarkers Assessing the Calcium Deposition in Coronary Artery Disease
Current Medicinal Chemistry Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine
Current Stem Cell Research & Therapy Screening, Evaluation, and Early Management of Acute Aortic Dissection in the ED
Current Cardiology Reviews Quantitative Ultrasound in Diagnosis of Metabolic Bone Diseases
Current Medical Imaging Infection, Infectious Agents and Vascular Disease
Reviews on Recent Clinical Trials Coronary Artery Ectasia-A Review of Current Literature
Current Cardiology Reviews The Location of Vascular Flap is Related with Daily Activity Patterns in Non-traumatic Acute Aortic Syndrome in a Chinese Population
Current Signal Transduction Therapy Significance of Hemodynamics Biomarkers, Tissue Biomechanics and Numerical Simulations in the Pathogenesis of Ascending Thoracic Aortic Aneurysms
Current Pharmaceutical Design Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors
Current Pharmaceutical Design Transforming Growth Factor β Signaling Perturbation in the Loeys-Dietz Syndrome
Current Medicinal Chemistry Novel Inflammatory Indices in Aortic Disease
Current Medicinal Chemistry Increased Paternal Age and Child Health and Development
Current Pediatric Reviews The Usefulness of Phalangeal Quantitative Ultrasound in the Assessment of Skeletal Status in Children and Adolescents
Current Medical Imaging