Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO

Title:Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO

Volume: 15 Issue: 6

Author(s): Hamzeh Kiyani*, Mohsen Tazari and Fatemeh Ghorbani

Affiliation:

• School of Chemistry, Damghan University, 36715-41167 Damghan,Iran

Keywords: 2-Aminobenzamide, aldehyde, 2, 3-dihydroquinazolin-4(1H)-one, green, nano-MgO, water.

Abstract: An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanocrystalline magnesium oxide (nano-MgO) as a catalyst from 2-aminobenzamide and various aldehydes/ketones under aqueous conditions at room temperature is described. Nano-MgO was synthesized by the precipitation and hydrothermal treatment of aqueous salt solution as reported previously. The structure of nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. Simple conditions, environmentally benign, good to excellent yields and comparatively shorter reaction times are the advantages of this protocol.

Cite this article as:

Kiyani Hamzeh *, Tazari Mohsen and Ghorbani Fatemeh , Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO, Letters in Organic Chemistry 2018; 15 (6) . https://dx.doi.org/10.2174/1570178614666170710094547