Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin

Author(s): Teresa Pasqua*, Tommaso Angelone*, Angela Spena and Maria Carmela Cerra

Volume 24, Issue 31, 2017

Page: [3356 - 3372] Pages: 17

DOI: 10.2174/0929867324666170616104759

Price: $65

conference banner
Abstract

Background: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biological role of CST in health and disease.

Methods: Structured search of bibliographic databases for peer-reviewed research literature.

Results: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis. CST influences the cardiocirculatory system acting both indirectly, via the autonomic nervous system, and directly by influencing the basal cardiac function, and the stretch-dependent myocardial performance. It also counteracts the effects of adrenergic stimulation on the heart and protects the myocardium from ischemia/reperfusion (I/R) injury, acting in pre- and postconditioning protection.

Conclusions: The knowledge on CST is constantly expanding, thanks to a growing number of human studies that document its involvement in physiological modulation and in many severe diseases, also revealing its applicative potential as a clinical biomarker.

Keywords: Chromogranin A, Catestatin, myocardial performance, cardioprotection, signal transduction, biological role, antimicrobial peptide, innate immunity, adipose, epidermal function, gut diseases.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy