折叠嗜铬粒蛋白A衍生肽catestatin的生物学作用

Title:Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin

Volume: 24 Issue: 31

关键词: 嗜铬粒蛋白A，催眠素，心肌表现，心脏保护，信号转导，生物作用，抗微生物肽，先天免疫，脂肪，表皮功能，肠道疾病。

摘要: Background: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biological role of CST in health and disease.

Methods: Structured search of bibliographic databases for peer-reviewed research literature.

Results: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis. CST influences the cardiocirculatory system acting both indirectly, via the autonomic nervous system, and directly by influencing the basal cardiac function, and the stretch-dependent myocardial performance. It also counteracts the effects of adrenergic stimulation on the heart and protects the myocardium from ischemia/reperfusion (I/R) injury, acting in pre- and postconditioning protection.

Conclusions: The knowledge on CST is constantly expanding, thanks to a growing number of human studies that document its involvement in physiological modulation and in many severe diseases, also revealing its applicative potential as a clinical biomarker.

Cite this article as:

Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin, Current Medicinal Chemistry 2017; 24 (31) . https://dx.doi.org/10.2174/0929867324666170616104759