Abstract
For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.
Keywords: Biosensors, Screening Kinase Inhibitors, protein phosphorylation, cancer, drug discovery.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Biosensors for Screening Kinase Inhibitors
Volume: 17 Issue: 22
Author(s): Nikhil Bhalla*Pedro Estrela
Affiliation:
- Okinawa Institute of Science and Technology Graduate University (OIST) 1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0412,Japan
Keywords: Biosensors, Screening Kinase Inhibitors, protein phosphorylation, cancer, drug discovery.
Abstract: For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.
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Cite this article as:
Bhalla Nikhil *, Estrela Pedro, Biosensors for Screening Kinase Inhibitors, Current Topics in Medicinal Chemistry 2017; 17 (22) . https://dx.doi.org/10.2174/1568026617666170531113233
DOI https://dx.doi.org/10.2174/1568026617666170531113233 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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