Abstract
Background: Polymer-peptide/protein conjugates immobilized on surface have gained considerable attention, mostly due to their broad scope of applications in biomedical fields. To optimize their properties, the combined knowledge of polymer chemistry and biochemistry has to be applied.
Method: The main methods to obtain such surfaces involve “grafting to” or “grafting from” of polymeric linkers with subsequent attachment of a peptide/protein. Alternatively, a “ready-made” conjugate may be grafted to the surface. Result: The structure of the polymer linker significantly influences the properties of the active surface, and a variety of physicochemical methods and tools have been successfully applied to study the structure-property relationship of these surfaces. Conclusion: This review outlines the applied synthetic strategies leading to covalently attached bioconjugates on the surface and the characterization techniques used to study those materials. The relevance of different linear polymeric linkers and their influence on the properties of the obtained materials is discussed.Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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