The Role of Phosphorus Trichloride and Phosphorous Acid in the Formation of α-Hydroxymethylenebisphosphonic Acids from the Corresponding Carboxylic Acids – A Mechanistic Overview

Title:The Role of Phosphorus Trichloride and Phosphorous Acid in the Formation of α-Hydroxymethylenebisphosphonic Acids from the Corresponding Carboxylic Acids – A Mechanistic Overview

Volume: 21 Issue: 16

Author(s): Dávid Illés Nagy, Alajos Grün, István Greiner and Gyorgy Keglevich*

Affiliation:

• Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest,Hungary

Keywords: Synthesis, α-Hydroxymethylenebisphosphonic acids (dronic acids), Phosphorus trichloride, Phosphorous acid, Intermediates, Reaction sequences/Protocols, Mechanisms.

Abstract: Background: Although the synthesis of α-hydroxymethylenebisphosphonic acids (dronic acids) and derivatives by reaction of the corresponding carboxylic acids (or its derivatives) with P-reagents, such as phosphorus trichloride, phosphorous acid and phosphoryl chloride formed the subject of many studies, in most cases, the selection of the P-reagents, their ratio, and the conditions (solvent and temperature) were not optimized.

Method: Selection of the appropriate P-reagents and their ratios, along with the conditions is possible, only if the reaction protocol (sequence of the steps) or the mechanism is known. For this purpose, the relevant information was extracted from the literature, critically discussed and the conclusions were drawn. Our own experiences are also summarized on the possible mechanisms, and on the related optimum set of the reaction parameters depending mainly on the nature of the solvent used.

Conclusion: This review gives a better understanding of the dronate chemistry, and promotes “greener” and more practical syntheses.

Cite this article as:

Nagy Illés Dávid , Grün Alajos , Greiner István and Keglevich Gyorgy *, The Role of Phosphorus Trichloride and Phosphorous Acid in the Formation of α-Hydroxymethylenebisphosphonic Acids from the Corresponding Carboxylic Acids – A Mechanistic Overview, Current Organic Chemistry 2017; 21 (16) . https://dx.doi.org/10.2174/1385272821666170417122441

DOI https://dx.doi.org/10.2174/1385272821666170417122441	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348