Abstract
Background: Early hematoma growth is not uncommon in patients with intracerebral hemorrhage. It is a devastating complication that independently predicts poor outcome. The early hematoma enlargement is usually defined as an absolute increase in hematoma volume of greater than 33% on repeat CT scan. To date, no ideal animal model can mimic the exact pathophysiological process of early hematoma growth.
Objective: This review of early hematoma enlargement in primary intracerebral hemorrhage discusses definitions, pathophysiology, risk factors, and novel treatment options aimed at improving outcomes. Conclusion: Novel imaging predictors such as CT angiography spot sign and CT blend sign may predict early hematoma growth in patients with intracerebral hemorrhage. Monitoring and modulation of blood pressure may improve outcomes. Rapid reduction of blood pressure to <140 mm Hg may be safe in patients with intracerebral hemorrhage.Keywords: Primary cerebral hemorrhage, hematoma enlargement, mechanisms, predictors.
Graphical Abstract
Current Drug Targets
Title:Early Hematoma Enlargement in Primary Intracerebral Hemorrhage
Volume: 18 Issue: 12
Author(s): Du Cao, Qi Li, Peichun Fu, John Zhang and Jun Yang*
Affiliation:
- Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing,China
Keywords: Primary cerebral hemorrhage, hematoma enlargement, mechanisms, predictors.
Abstract: Background: Early hematoma growth is not uncommon in patients with intracerebral hemorrhage. It is a devastating complication that independently predicts poor outcome. The early hematoma enlargement is usually defined as an absolute increase in hematoma volume of greater than 33% on repeat CT scan. To date, no ideal animal model can mimic the exact pathophysiological process of early hematoma growth.
Objective: This review of early hematoma enlargement in primary intracerebral hemorrhage discusses definitions, pathophysiology, risk factors, and novel treatment options aimed at improving outcomes. Conclusion: Novel imaging predictors such as CT angiography spot sign and CT blend sign may predict early hematoma growth in patients with intracerebral hemorrhage. Monitoring and modulation of blood pressure may improve outcomes. Rapid reduction of blood pressure to <140 mm Hg may be safe in patients with intracerebral hemorrhage.Export Options
About this article
Cite this article as:
Cao Du , Li Qi, Fu Peichun , Zhang John and Yang Jun *, Early Hematoma Enlargement in Primary Intracerebral Hemorrhage, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450118666170427151011
DOI https://dx.doi.org/10.2174/1389450118666170427151011 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Quality and Safety in Pediatric Complex Care
Current Pediatric Reviews Aquaporins as Targets for Drug Discovery
Current Pharmaceutical Design Viral Encephalitis: Current Treatments and Future Perspectives
Central Nervous System Agents in Medicinal Chemistry Papillary Tumor of the Pineal Region with Parinaud Syndrome: A Case Report
Current Medical Imaging Perinatal and Neonatal Outcomes of Lithium-Treated and Untreated Bipolar Women During Pregnancy: A Review of Present Literature
Current Psychopharmacology Differential Gene Expression in the Nucleus Accumbens and Frontal Cortex of Lewis and Fischer 344 Rats Relevant to Drug Addiction
Current Neuropharmacology Application of NMR to the Study of Cells and Body Fluids
Current Organic Chemistry Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry FDG PET/MR Imaging in Major Neurocognitive Disorders
Current Alzheimer Research “Epileptic Encephalopathy” of Infancy and Childhood: Electro-Clinical Pictures and Recent Understandings
Current Neuropharmacology Neuroimaging of Non-Accidental Injury
Current Pediatric Reviews Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial
Current Alzheimer Research Fork Head Transcription Factors
Current Genomics Congenital Malformations Attributed to Prenatal Exposure to Cyclophosphamide
Anti-Cancer Agents in Medicinal Chemistry Intracranial Non-traumatic Aneurysms in Children and Adolescents
Current Pediatric Reviews Recent Advances in Treatment Approaches to Gaucher Disease
Current Pharmaceutical Biotechnology DLPF Targeted Repetitive Transcranial Magnetic Stimulation Improves Brain Glucose Metabolism Along with the Clinical and Electrophysiological Parameters in CBD Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets BDNF/NF-κB Signaling in the Neurobiology of Depression
Current Pharmaceutical Design Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Current Medicinal Chemistry Menstrual Disorders Related to Eating Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets