Early Hematoma Enlargement in Primary Intracerebral Hemorrhage

Title:Early Hematoma Enlargement in Primary Intracerebral Hemorrhage

Volume: 18 Issue: 12

Author(s): Du Cao, Qi Li, Peichun Fu, John Zhang and Jun Yang*

Affiliation:

• Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing,China

Keywords: Primary cerebral hemorrhage, hematoma enlargement, mechanisms, predictors.

Abstract: Background: Early hematoma growth is not uncommon in patients with intracerebral hemorrhage. It is a devastating complication that independently predicts poor outcome. The early hematoma enlargement is usually defined as an absolute increase in hematoma volume of greater than 33% on repeat CT scan. To date, no ideal animal model can mimic the exact pathophysiological process of early hematoma growth.

Objective: This review of early hematoma enlargement in primary intracerebral hemorrhage discusses definitions, pathophysiology, risk factors, and novel treatment options aimed at improving outcomes.

Conclusion: Novel imaging predictors such as CT angiography spot sign and CT blend sign may predict early hematoma growth in patients with intracerebral hemorrhage. Monitoring and modulation of blood pressure may improve outcomes. Rapid reduction of blood pressure to <140 mm Hg may be safe in patients with intracerebral hemorrhage.

Cite this article as:

Cao Du , Li Qi, Fu Peichun , Zhang John and Yang Jun *, Early Hematoma Enlargement in Primary Intracerebral Hemorrhage, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450118666170427151011

DOI https://dx.doi.org/10.2174/1389450118666170427151011	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592