Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications

Title:Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications

Volume: 17 Issue: 20

Author(s): Yong Siang Ong, Liqian Gao, Karunakaran A. Kalesh, Zhiqiang Yu*, Jigang Wang, Chengcheng Liu, Yiwen Li, Hongyan Sun*Su Seong Lee*

Affiliation:

• School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, Guangdong 510515,China

• Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong,China

• Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669,Singapore

Keywords: Cyclic peptide, Cyclization, Bead-based library, Phage display, mRNA display, Computational.

Abstract: Cyclic peptides, owing to their good stability, high resistance to exo- and to some extent endo-peptidases, enhanced binding affinity and selectivity towards target biomolecules, are actively investigated as biochemical tools and therapeutic agents. In this review, we discuss various commonly utilized synthetic strategies for cyclic peptides and peptoids (peptidomimetics), their important screening methods to identify the bioactive cyclic peptides and peptoids such as combinatorial beadbased peptide library, phage display, mRNA display etc. and recent advances in their applications as bioactive compounds. Lastly, we also make a summary and provide an outlook of the research area.

Cite this article as:

Ong Siang Yong, Gao Liqian, Kalesh A. Karunakaran, Yu Zhiqiang*, Wang Jigang, Liu Chengcheng, Li Yiwen, Sun Hongyan*, Lee Seong Su*, Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications, Current Topics in Medicinal Chemistry 2017; 17 (20) . https://dx.doi.org/10.2174/1568026617666170224121658