Development and Characterization Pulsatile Microspheres of Nifedipine for Hypertension

Title:Development and Characterization Pulsatile Microspheres of Nifedipine for Hypertension

Volume: 11 Issue: 1

Author(s): Rahul Taneja*Ghanshyam D. Gupta

Affiliation:

• Department of Pharmaceutical Research Division, Amar Shaheed Baba AjIt Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India; Affiliated to IKG Punjab Technical University, Jalandhar,India

Keywords: Hypertension, pulsatile, nifedipine, microspheres, polymers, carbopol.

Abstract: Background: To develop pulsatile microspheres of Nifedipine blend of polymers Carbopol 971P and Eudragit RS100 for antihypertensive to release the drug at a particular lag time.

Methods: Pulsatile nifedipine microspheres were prepared using the blend of Carbopol 971P and Eudragit RS100 at different ratios in a mixture of solvents. Formulations were prepared and optimized on the basis of particle size, percentage yield and drug entrapment efficiency. Optimized formulations were further analyzed at different resolutions per minute (rpm) by optical microscopy, scanning electron microscopy (SEM), in-vitro dissolution studies and kinetics model. The most promising formulation was compared with the marketed products. The recent patents on microsphere used for hypertension for drug used Liensinine (CN104757561). Dopamine antagonist (US20030069232A1), Human Serum Albumin (EP19990304616) and Omeprazole (IN2107/DEL/2014) helped in selecting the drug and polymers.

Results: The formulated microspheres had mean particle size ranging from 177.31 to 277.48 µm. Formulation F83 showed slow release of drug initially for 4 h and drastically release of drug enhanced at a particular lag time (Showed pulsatile release) after 6 h. However, conventional marketed products showed maximum release initially at 1 h and decreased gradually while controlled released marketed product showed sustained pattern.

Conclusion: On the basis of data formulation F83 showed slow release and at a particular lag time followed by pulsatile release pattern and followed first order kinetics model. It was concluded that the formulated nifedipine pulsatile dosage form could be useful in the treatment of hypertension.

Cite this article as:

Taneja Rahul*, D. Gupta Ghanshyam , Development and Characterization Pulsatile Microspheres of Nifedipine for Hypertension, Recent Patents on Drug Delivery & Formulation 2017; 11 (1) . https://dx.doi.org/10.2174/1872211311666170213104321

DOI https://dx.doi.org/10.2174/1872211311666170213104321	Print ISSN 1872-2113
Publisher Name Bentham Science Publisher	Online ISSN 2212-4039