Molecularly Imprinted Polymer of Colocynthin, An Effective Tool for Quality Control of Citrullus colocynthis Extracts

Title:Molecularly Imprinted Polymer of Colocynthin, An Effective Tool for Quality Control of Citrullus colocynthis Extracts

Volume: 14 Issue: 3

Author(s): Ramezani Farid, Khanavi Mahnaz, Shams Ardekani Mohammad Reza, Sellergren Börje, Eftekhari Mahdieh, Rastegar Hossein and Shekarchi Maryam*

Affiliation:

• Food and Drug Control Laboratories and Research Center, MOH and ME, P.O. Box 11136-15911, Tehran,Iran

Keywords: Citrullus colocynthis, colocynthin, traditional medicine, molecularly imprinted polymer, colocynthin, high-performance liquid chromatography.

Abstract: Background: Different parts of Colocynth, Citrullus colocynthis (L.) Schrad., are used in traditional phytotherapy and homeopathy.

Objective: In our new approach, a molecularly imprinted polymer was synthesized to absorb colocynthin, the major plant marker, and its capability was evaluated using HPLC-UV.

Method: A new method was considered to achieve optimal conditions. FT-infrared, N2 adsorption porosimetry, fluorescent and scanning electron microscopy and thermo gravimetric profile of the polymers were studied. The imprinted polymer was applied as molecularly imprinted solid phase extraction sorbent to enrich colocynthin from colocynth oil extract, a traditional medicine dosage form.

Results: The imprinted polymer showed high capacity and affinity toward colocynthin. Physical assessments demonstrated no major differences between imprinted and nonimprinted polymers. The imprinted polymer was able to absorb colocynthin more efficiently than non-imprinted and control simple solvent extraction from the real sample.

Conclusion: In conclusion, this polymer is capable of being applied as a promising adsorbent for analysis of colocynth traditional medicine products.

Cite this article as:

Farid Ramezani, Mahnaz Khanavi, Ardekani Mohammad Reza Shams, Börje Sellergren, Mahdieh Eftekhari, Hossein Rastegar and Maryam Shekarchi*, Molecularly Imprinted Polymer of Colocynthin, An Effective Tool for Quality Control of Citrullus colocynthis Extracts, Current Drug Discovery Technologies 2017; 14 (3) . https://dx.doi.org/10.2174/1570163814666170104152226

DOI https://dx.doi.org/10.2174/1570163814666170104152226	Print ISSN 1570-1638
Publisher Name Bentham Science Publisher	Online ISSN 1875-6220