Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer

Title:Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer

Volume: 12 Issue: 3

Author(s): Md. Emranul Karim, Rozita Rosli and Ezharul H. Chowdhury

Affiliation:

Keywords: Cancer, multi-functional nanoparticle, anti-cancer drug, active targeting, passive targeting, EPR effect, controlled release.

Abstract: Despite being widely used for cancer treatment, conventional chemotherapeutic regimens based on anti-cancer drugs possess significant drawbacks in discriminating between normal and cancer cells, leading to detrimental effects on healthy tissues. The development of nano-formulations encapsulating the chemotherapy drugs is highly expected to improve the anti-cancer activities with favorable pharmacokinetic profile and consequentially minimized side-effects. Several organic and inorganic nanoparticles have received tremendous attention as carriers of various anticancer drugs in pre-clinical and clinical settings. In this review, we discuss on the progress of formulating and investigating various nano-formulationsin treating different cancers, with an emphasis on in vivo studies utilizing the nanoparticles for carrying small molecular weight anti-cancer drugs and focusing on the biocompatibility, targeting capability, cellular uptake, and the tumor regression efficacy of those nano-formulations.

Cite this article as:

Karim Emranul Md., Rosli Rozita and Chowdhury H. Ezharul, Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer, Current Cancer Therapy Reviews 2016; 12 (3) . https://dx.doi.org/10.2174/1573394712666160919101827