Abstract
The increasing knowledge of cellular and molecular mechanisms of human diseases allows envisaging the gene therapy by sonoporation as an emerging and promising therapeutic alternative. Sonoporation combines the local application of ultrasound waves and the intravascular or intratissue administration of gas microbubbles. In such a way, the permeability of vessels and tissues to the poorly permeant molecules is transiently increased. Ultrasound based modality offers new opportunities since ultrasound can be easily focused on a target tissue or organ and hence gene delivery and expression should be limited to the insonified region. Consequently, it might be possible to develop an efficient and safe tissue- or organ-specific delivery method by microbubble targeting and focused ultrasound. This review focuses on the current knowledge of sonoporation fundamentals and mechanisms. The sonoporation procedure and current preclinical trials will be then presented. Finally, the new challenges of sonoporation will be discussed.
Keywords: Sonoporation, ultrasound, microbubble, gene delivery, gene therapy, intravascular, intratissue, electroporation
Current Gene Therapy
Title:In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects
Volume: 13 Issue: 1
Author(s): Jean-Michel Escoffre, Aya Zeghimi, Anthony Novell and Ayache Bouakaz
Affiliation:
Keywords: Sonoporation, ultrasound, microbubble, gene delivery, gene therapy, intravascular, intratissue, electroporation
Abstract: The increasing knowledge of cellular and molecular mechanisms of human diseases allows envisaging the gene therapy by sonoporation as an emerging and promising therapeutic alternative. Sonoporation combines the local application of ultrasound waves and the intravascular or intratissue administration of gas microbubbles. In such a way, the permeability of vessels and tissues to the poorly permeant molecules is transiently increased. Ultrasound based modality offers new opportunities since ultrasound can be easily focused on a target tissue or organ and hence gene delivery and expression should be limited to the insonified region. Consequently, it might be possible to develop an efficient and safe tissue- or organ-specific delivery method by microbubble targeting and focused ultrasound. This review focuses on the current knowledge of sonoporation fundamentals and mechanisms. The sonoporation procedure and current preclinical trials will be then presented. Finally, the new challenges of sonoporation will be discussed.
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Escoffre Jean-Michel, Zeghimi Aya, Novell Anthony and Bouakaz Ayache, In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects, Current Gene Therapy 2013; 13 (1) . https://dx.doi.org/10.2174/1566523211313010002
DOI https://dx.doi.org/10.2174/1566523211313010002 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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