Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms

Title:Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms

Volume: 25 Issue: 39

Author(s): Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsouraki, Dimitrios Michmizos, Nagendra Sastry Yarla, Vadim V. Tarasov, Ghulam Md Ashraf and Gjumrakch Aliev*

Affiliation:

• Sechenov First Moscow State Medical University, 119991, Moscow,Russian Federation

Keywords: Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.

Abstract: A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

Cite this article as:

Leszek Jerzy, Trypka Elżbieta, Koutsouraki Euphrosyni, Michmizos Dimitrios, Yarla Sastry Nagendra, Tarasov V. Vadim, Ashraf Md Ghulam and Aliev Gjumrakch*, Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms, Current Medicinal Chemistry 2018; 25 (39) . https://dx.doi.org/10.2174/0929867323666160902152829