摘要
最近的研究结果表明,晚期抑郁症(LLD)典型的生物学和临床特征有很多。 LLD与认知障碍的密切关联现已得到充分证明并得到证实。 然而,目前尚不清楚抑郁症是否会导致认知能力下降,更严重的是导致痴呆症。 本综述文章中提出的工作表明抑郁症和痴呆症经常强烈共存,即使因果关系仍然很大程度上不透明。
关键词: 衰老,阿尔茨海默病,抑郁症,痴呆症,BDNF晚年抑郁症
Current Medicinal Chemistry
Title:Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms
Volume: 25 Issue: 39
关键词: 衰老,阿尔茨海默病,抑郁症,痴呆症,BDNF晚年抑郁症
摘要: A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
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Cite this article as:
Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms, Current Medicinal Chemistry 2018; 25 (39) . https://dx.doi.org/10.2174/0929867323666160902152829
DOI https://dx.doi.org/10.2174/0929867323666160902152829 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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