Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives

Title:Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives

Volume: 14 Issue: 3

Author(s): Yu Sun, Qing-Hao Jin, Yan Han, Di Yu, Qiu-Ping Dai and Zhou-Jun Zheng

Affiliation:

Keywords: Benzo[d]-1, 2, 3-triazole, FST, neurotransmitters, MES, antidepressant.

Abstract: Background: 21 novel 1-alkoxy-1H-benzo[d]-1,2,3-triazole compounds were designed, prepared and evaluated for their antidepressant and anticonvulsant effects in mice.

Method: Compound 19 significantly decreased immobility time in the FST without altering the locomotor activity in the open field test, and exhibited higher levels of efficacy than the reference standard fluoxetine. Compound 19 significantly increased 5-HT, NE and 5-HIAA levels in mice brain, implying that the antidepressant activity might be mediated by these neurotransmitters. In the seizure test, compound 19 also showed better anticonvulsant activity against MES, whereas had not shown neurotoxicity (300 mg/kg).

Conclusion: Our data indicated that compound 19 could potentially be used as the antidepressant drug in patients with epilepsy.

Cite this article as:

Sun Yu, Jin Qing-Hao, Han Yan, Yu Di, Dai Qiu-Ping and Zheng Zhou-Jun, Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives, Letters in Drug Design & Discovery 2017; 14 (3) . https://dx.doi.org/10.2174/1570180813666160826113018

DOI https://dx.doi.org/10.2174/1570180813666160826113018	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X