A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens

Title:A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens

Volume: 23 Issue: 10

Author(s): Dakshinamurthy Sivakumar and Thirunavukkarasu Sivaraman

Affiliation:

Keywords: Apoptosis, Bcl-2 family proteins, anti-cancer compounds and structure-function relationships.

Abstract: Cancer cells evade apoptosis, which is regulated by proteins of Bcl-2 family in the intrinsic pathways. Numerous experimental three-dimensional (3D) structures of the apoptotic proteins and the proteins bound with small chemical molecules/peptides/proteins have been reported in the literature. In this review article, the 3D structures of the Bcl-2 family proteins from Homo sapiens and as well complex structures of the anti-apoptotic proteins bound with small molecular inhibitors reported in the literature to date have been comprehensively listed out and described in detail. Moreover, the molecular mechanisms by which the Bcl-2 family proteins modulate the apoptotic processes and strategies for designing antagonists to anti-apoptotic proteins have been concisely discussed.

Cite this article as:

Sivakumar Dakshinamurthy and Sivaraman Thirunavukkarasu, A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens, Protein & Peptide Letters 2016; 23 (10) . https://dx.doi.org/10.2174/0929866523666160719094636